Nrf2: A Critical Regulator of the Innate Immune Response
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 11423
Special Issue Editor
Special Issue Information
Dear Colleagues,
The transcription factor Nrf2 is a well-known for its role in the anti-oxidant response, where it regulates an array of antioxidant and detoxifying genes. At homeostasis, Nrf2 is targeted for degradation by the cellular protein KEAP1. Modulation of KEAP1 in response to oxidative stress is well described and leads to the accumulation of Nrf2 and the subsequent expression of its target gets by the binding of Nrf2 to antioxidant response elements (AREs). More recently, the activation of Nrf2 was demonstrated to occur in response to infection and to the stimulation of cellular innate receptors with pathogen-associated molecular patterns such as LPS. The activation of Nrf2 in this context co-occurs with metabolic reprogramming in macrophages and the subsequent increases in oxidative stress, as well as in the abundance of distinct metabolites with electrophilic properties. The potential of such metabolites to activate Nrf2 has drawn a great deal of attention, and derivatives of the electrophilic metabolite itaconate have now been demonstrated to directly activate Nrf2. Further, emerging evidence now suggests that Nrf2 occupies a central and hitherto unappreciated position as a regulator of innate immune responses in response to oxidative or metabolic stress. This includes the direct inhibition of STING-dependent IFN responses and of the release of pro-inflammatory cytokines in response to Toll-like receptor signaling. We are putting together a Special Issue of the journal Antioxidants with a focus on the interaction between Nrf2 and innate immune responses. The aim of this Special Issue is to advance our understanding of the role Nrf2 plays in innate immune responses.
Dr. Christian Kanstrup Holm
Guest Editor
Manuscript Submission Information
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Keywords
- Innate immunology
- Inflammation
- Anti-oxidant response
- Metabolic reprogramming
