Oxidative Stress in Herbal Medicine

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 4315

Special Issue Editor


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Guest Editor
Center for Integrative Medicine, Tsukuba University of Technology, Tsukuba, Japan
Interests: oxidative stress; free radicals; herbal medicine; Kampo: Japanese traditional herbal medicine; nephrology; electron spin resonance; Nrf2

Special Issue Information

Dear Colleagues,

Expectations for herbal medicines are now growing on a global scale. Antioxidative effects are the central pharmacological activity of herbal medicines, which are used both in the East and the West and in both traditional and modern approaches. The characteristics of herbal medicines, which differ from those of modern drug therapy, are based on the composition of several active ingredients produced as a result of the combination of crude drug components that generate their specific pharmacological effects. This is also applicable to their antioxidant activities. While purified natural antioxidants and synthesised antioxidative compounds usually have a single or a few reactive points, the reactive points of herbal medicines are multiple and diverse in complex oxidative-stress-related reactions. These effects are mainly antioxidative but may sometimes be pro-oxidative. Consequently, herbal medicines do not simply reduce oxidative stress, but rather cause more complex oxidative–antioxidative shifts, which are deeply related to their unique pharmacological effects.

In this Special Issue, we focus on the unique antioxidative effects of herbal medicines, which differ from those of modern drug therapy, leading to the creation of a de novo strategy to control oxidative stress. Both basic and clinical research articles are welcome. We look forward to your submission.

Prof. Dr. Aki Hirayama
Guest Editor

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Keywords

  • herbal medicine
  • oxidative stress
  • reactive oxygen species
  • reactive nitrogen species
  • antioxidants
  • control of oxidative stress
  • lipid peroxidation
  • antioxidants
  • Nrf2–Keap1 system
  • NFkB

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Published Papers (1 paper)

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Research

19 pages, 1702 KiB  
Article
Wolfberry (Lycium barbarum) Consumption with a Healthy Dietary Pattern Lowers Oxidative Stress in Middle-Aged and Older Adults: A Randomized Controlled Trial
by Darel Wee Kiat Toh, Wan Yee Lee, Hanzhang Zhou, Clarinda Nataria Sutanto, Delia Pei Shan Lee, Denise Tan and Jung Eun Kim
Antioxidants 2021, 10(4), 567; https://doi.org/10.3390/antiox10040567 - 7 Apr 2021
Cited by 18 | Viewed by 3237
Abstract
Incorporating zeaxanthin-rich wolfberry (Lycium barbarum) into a healthy dietary pattern may augment its antioxidant potential. The present 16-week, parallel design randomized controlled trial aimed to investigate the impact of adhering to a healthy dietary pattern, either with or without whole dried [...] Read more.
Incorporating zeaxanthin-rich wolfberry (Lycium barbarum) into a healthy dietary pattern may augment its antioxidant potential. The present 16-week, parallel design randomized controlled trial aimed to investigate the impact of adhering to a healthy dietary pattern, either with or without whole dried wolfberry (15 g/d) on oxidative stress status (plasma malondialdehyde and 8-iso-prostaglandin F2α) in middle-aged and older adults. Changes to carotenoids status (plasma and skin carotenoids) and body composition were further evaluated to explore potential mechanisms which underlie the antioxidant properties of wolfberry. Plasma 8-iso-prostaglandin F2α, plasma zeaxanthin and skin carotenoids status were significantly raised in the wolfberry consuming group (n = 22; p < 0.05) compared to the control group which showed no changes (n = 18). Likewise in the wolfberry group only, inverse association was observed between the change values of plasma zeaxanthin and plasma 8-iso-prostaglandin F2α (−0.21 (−0.43, 0.00) ng/µmol, regression coefficient (95% CI); p = 0.05). Wolfberry consumption with a healthy dietary pattern may serve as a dietary strategy to attenuate lipid peroxidation among middle-aged and older adults who are at a heightened risk of oxidative stress induced age-related disorders. The antioxidant properties of wolfberry may be attributed to its rich zeaxanthin content. Full article
(This article belongs to the Special Issue Oxidative Stress in Herbal Medicine)
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