Antioxidants

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Special Issue Editors

Dr. Valter Travagli

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Guest Editor

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy
Interests: pharmaceutical technology; pharmaceutical care; quality context; personalized medicine; safety issues

Dr. Gerardo Tricarico

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Co-Guest Editor

1 Eastern Piedmont University - School of Medicine, Department of Health Science (adjunct professor)
2 ASL "VC" Sant’Andrea Vercelli Hospital Odontostomatology Outpatient Clinic (Dentist Manager)
Interests: ozone therapy; stem cells; regenerative medicine; electromedicine; dentistry

Special Issue Information

Dear Colleagues,

Since Denham Harman published, in 1956, the paper “Aging: a theory based on free radical and radiation chemistry”, significant advances have been made in understanding the influence of chronic oxidative stress in many diseases such as diabetes, cancer, and neurological and cardiovascular pathologies. In recent years, authoritative authors have clarified in depth the importance of pro-oxidant/antioxidant balance at the level of cellular components and cellular metabolism involved in cell proliferation and adaptation. Such opposing effects are expected due to differences in temporal (acute vs. chronic) and spatial (subcellular setting vs. bloodstream) formation of reactive species. Both the correct use and dosage of chemical agents with pro-oxidant action are the basis of therapeutic approaches characterized by a paradoxical effect on the organism. The biochemical principles and the hormetic aspects in this regard are now defined.

We invite you to submit your latest research findings or a review article to this Special Issue which will bring together current research concerning oxidative eustress/distress balance of oxidative treatments such as intravenous hydrogen peroxide, intravenous high dose of ascorbate, hyperbaric oxygen therapy, and ozonated autohemotherapy. Epigenetics, translational research, and regenerative medicine, as well as personalized medicine are the main frames. Clinical contributions from veterinary practice are equally welcome.

We look forward to your contribution.

Dr. Valter Travagli
Dr. Gerardo Tricarico
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Please note that for papers submitted after 31 December 2020 an APC of 2000 CHF applies.

Keywords

Chronic oxidative stress diseases
Oxidative therapies
Hyperbaric oxygen therapy
Intravenous hydrogen peroxide therapy
Intravenous high-dose vitamin C
Ozone therapy

Published Papers (2 papers)

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Research

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14 pages, 942 KiB

Open AccessArticle

The Relationship between Ozone and Human Blood in the Course of a Well-Controlled, Mild, and Transitory Oxidative Eustress

by Gerardo Tricarico and Valter Travagli

Antioxidants 2021, 10(12), 1946; https://doi.org/10.3390/antiox10121946 - 4 Dec 2021

Cited by 14 | Viewed by 4343

Abstract

In the last twenty years there has been a proliferation of articles on the therapeutic use of ozone. As it is well-known, the term ozone therapy is very broad. It ranges from either systemic or loco-regional administration of unstable gaseous oxygen/ozone mixtures to the topical application of stable ozonated derivatives. Anyway, in relation to the absence of specific receptors and the extreme reactivity with the biological liquids with which it comes into contact, gaseous ozone cannot be classified as either a drug or a pro-drug. When the gaseous ozone impacts a biological matrix, both reactive oxygen species (ROS) and lipid oxidation products (LOPs) are formed. They represent the effector molecules responsible for modulating the therapeutic activity in the body. Apart from the merits of the action mechanisms resulting from the use of ozone, this article seeks to validate the practice of ozone therapy as an adjuvant treatment in full compliance with the physiology of the whole organism. Full article

(This article belongs to the Special Issue Paradoxical Oxidative Therapies in Chronic Oxidative Stress Diseases)

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Review

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17 pages, 885 KiB

Open AccessReview

Antioxidant Paradox in Male Infertility: ‘A Blind Eye’ on Inflammation

by Sulagna Dutta, Pallav Sengupta, Shubhadeep Roychoudhury, Srikumar Chakravarthi, Chee Woon Wang and Petr Slama

Antioxidants 2022, 11(1), 167; https://doi.org/10.3390/antiox11010167 - 16 Jan 2022

Cited by 17 | Viewed by 3758

Abstract

The pathophysiology of male infertility involves various interlinked endogenous pathways. About 50% of the cases of infertility in men are idiopathic, and oxidative stress (OS) reportedly serves as a central mechanism in impairing male fertility parameters. The endogenous antioxidant system operates to conserve the seminal redox homeostasis required for normal male reproduction. OS strikes when a generation of seminal reactive oxygen species (ROS) overwhelms endogenous antioxidant capacity. Thus, antioxidant treatment finds remarkable relevance in the case of idiopathic male infertility or subfertility. However, due to lack of proper detection of OS in male infertility, use of antioxidant(s) in some cases may be arbitrary or lead to overuse and induction of ‘reductive stress’. Moreover, inflammation is closely linked to OS and may establish a vicious loop that is capable of disruption to male reproductive tissues. The result is exaggeration of cellular damage and disruption of male reproductive tissues. Therefore, limitations of antioxidant therapy in treating male infertility are the failure in the selection of specific treatments targeting inflammation and OS simultaneously, two of the core mechanisms of male infertility. The present review aims to elucidate the antioxidant paradox in male infertility treatment, from the viewpoints of both induction of reductive stress as well as overlooking the inflammatory consequences. Full article

(This article belongs to the Special Issue Paradoxical Oxidative Therapies in Chronic Oxidative Stress Diseases)

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