Redox Homeostasis in Bone Health
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 5395
Special Issue Editors
Interests: antioxidant functions; redox balance; bone metabolism; osteoporosis; intervertebral disc degeneration
Special Issue Information
Dear Colleagues,
Bones play pivotal roles in the human body by providing structure, protecting organs, anchoring muscles, and storing calcium. Bone remodeling occurs continuously as evidenced by new bone formation coupled with old bone resorption. Bone tissue injury can initiate a variety of bone-related diseases, e.g., osteoporosis (OP) and osteoarthritis (OA). Therefore, protecting bone health is essential for human health.
Redox homeostasis, or redox signaling, helps maintain a normal physiological steady state. Inharmonic oxidative stress and antioxidant properties can trigger over-production of reactive oxygen species (ROS), leading to a series of cellular dysfunctions. Accumulated damage from mitochondrial ROS or endoplasmic reticulum (ER) stress is believed to be a major contributor to bone metabolism imbalance.
This Special Issue aims to provide a broad and updated overview of the involvement of redox homeostasis in bone health. An understanding of the interaction between oxidative stress and bone health, and their role in bone-related diseases, e.g., OA, OP, intervertebral disc degeneration (IVDD), etc., will aid the development of strategies for combating these pathological conditions. Original research and review articles are welcome.
We invite you to submit your latest research findings or a review article to this Special Issue, which will bring together current research concerning redox homeostasis in bone metabolism. Potential topics include, but are not limited to, the following:
- Sources and regulation of ROS in bone-related diseases;
- Mechanisms of oxidative-stress-mediated signaling in bone health;
- Interaction between ROS production, mitochondrial functions, and ER stress;
- Roles of antioxidants in the treatment of bone dysfunction and bone-related diseases;
- New strategies to interfere with oxidative stress and antioxidant strategies.
We look forward to your contributions.
Dr. Fan He
Dr. Yong Xu
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- redox homeostasis
- bone metabolism
- bone disease
- oxidative stress
- antioxidant enzymes
- mitochondrial ROS
