Mitochondrial Superoxide Dismutase in Cancer Biology and Therapy
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Antioxidant Enzyme Systems".
Deadline for manuscript submissions: closed (15 February 2022) | Viewed by 16731
Special Issue Editors
Interests: sirtuins (ISIRT3); mitochondrial metabolism; acetylation; MnSOD; ACSS1
Special Issue Information
Dear Colleagues,
Since the original proposal that disruptions in superoxide metabolism were fundamental to malignant transformation and cancer progression (PMID: 217531; PMID: 6254638; PMID: 6253771; PMID: 6259499), many studies have shown that the mitochondrial superoxide dismutase enzyme can act both as a suppressor of the malignant phenotype as well as a promoter of progression to a more malignant state depending on the stage of carcinogenesis. Furthermore, manipulations of mitochondrial superoxide/hydrogen peroxide metabolism, including post-translational acetylation modifications by sirtuins, can be targeted to improve cancer therapy, and several are currently in clinical trials. In this special issue of Antioxidants, specific mechanistic aspects of the role that mitochondrial superoxide dismutase plays, as well as the detoxification enzymes that regulate its cellular levels, in malignant transformation and cancer progression will be explored with a focus on exploiting fundamental differences in superoxide metabolism in cancer versus normal cells for the purpose of improving cancer therapy outcomes.
Prof. Dr. David Gius
Prof. Dr. Douglas R. Spitz
Guest Editors
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