Vitamin C in Cancer: From Mechanistic Insights to Clinical Intervention Trials
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (15 October 2021) | Viewed by 14164
Special Issue Editor
Interests: ascorbate; cancer therapy; tumour hypoxia; hypoxia-inducible factors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Robust clinical evidence for the efficacy of high dose vitamin C (ascorbate) for cancer treatment remains elusive. However, due to an improved understanding of the mechanism/s of action of ascorbate and encouraging data from small intervention trials, there is increasing interest in this vitamin.
To date, there are no confirmatory randomised controlled clinical trials on high dose ascorbate infusions in patients with cancer, in part due to the fact that there are still numerous outstanding questions. In particular, it is clear that ascorbate treatment is not effective in all patients, but that it modifies numerous vital molecular pathways, and may selectively eradicate cancer cells. It remains unclear who may benefit, what doses are required and how often, which molecular mechanisms are most important and how ascorbate interacts with other treatments.
This Antioxidants Special Issue aims to collect and publish studies aimed at answering some of these remaining questions and to provide an unbiased source of scientific information. We invite original research reports, and will consider reviews, meta-analyses and scientific hypotheses. Submissions of negative or controversial findings from robust scientific studies are also encouraged. We are interested in quantitative, biochemical and molecular analyses of cells in culture, in relevant animal models (knock-out mice, guinea pigs, zebrafish), in clinical samples and from patient studies.
Antioxidants are an open access scientific journal with a new Impact Factor (2020) of 5.014. An Article Processing Charge (APC) of 2000 CHF applies to papers accepted after peer review.
Dr. Gabi Dachs
Guest Editor
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Keywords
- enzyme cofactor
- molecular pathways
- antioxidant and pro-oxidant activity
- cancer types
- immune cells
- tumour microenvironment
- clinical trials
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