Antioxidants and Age-Related Ocular Diseases
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 71664
Special Issue Editors
Interests: pharmacology; ageing; eye diseases; cell stress; cytoprotection; RNA-binding proteins
Special Issue Information
Dear Colleagues,
Evidence in the literature suggests that in ageing there is an imbalance between increased pro-oxidant stress and impaired physiological detoxifying systems. Oxidative stress is a known factor inducing ageing and degeneration, and it is likely involved in the etiopathogenesis of many age-related ocular diseases affecting the retina, optic nerve, or other eye tissues. Indeed, oxidative-stress-induced effects include, but are not limited to, damage to cellular components (nucleic acids, proteins, lipids, organelles); protein aggregation; alteration of metabolism and biochemical processes; activation of signaling cascades linked to stress response, inflammation, and cell death; and changes in the gene expression (at both transcriptional and post-transcriptional levels) or function of enzymes/structural proteins. As such, endogenous detoxifying factors and repair systems play a vital role in maintaining cellular/tissue homeostasis. Accordingly, natural and synthetic molecules acting on the above targets to either counteract oxidative stress or improve protective systems may be of pharmacological interest in contexts featuring elevated oxidative stress.
We invite you to submit your latest original research findings (in vitro, in/ex vivo, and human studies) or a review article relating to any of the mentioned topics to this Special Issue, which will contribute in clarifying the role played by the oxidative stress in the molecular and cellular mechanisms underlying age-related ocular pathologies, as well as the relevance of detoxifying endogenous and exogenous factors in eye health and disease.
Prof. Dr. Marialaura Amadio
Dr. Adrian Smedowski
Guest Editor
Manuscript Submission Information
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Keywords
- Aging
- Eye
- Ocular disease
- Oxidative stress
- Antioxidant
- Detoxifying
- Cytoprotection
- Pharmacological modulation
- Molecular biology
- Cell biology
- Biochemistry
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