Cellular Redox Homeostasis
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 31119
Special Issue Editors
2. Laboratory of Redox Biology, Departments of Pharmacology and Physiology, Hungarian Veterinary Medical University, Budapest, Hungary
Interests: gene regulation; cell and organismal physiology; genetics; embryology; redox biology; biochemistry; metabolism; mouse models
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The health of cells and organisms depends on the maintenance of correctly balanced cytosolic and organellar redox states. The major cellular players in maintaining this balance are (1) the glutathione and thioredoxin systems; (2) the NADPH-regenerating systems that provide reducing power to these systems; and (3) the glutathione- or thioredoxin-dependent reductase enzymes, including peroxidases and others, that ultimately utilize this reducing power to eliminate oxidants or repair oxidative damage. Cells invest considerable resources into these systems, and deficiencies of these systems underlie many diseases. Diverse pathological states, both within experimental models and in the clinic, have been shown to respond favorably to supplemental antioxidant treatments, and a rich body of literature documents the therapeutic values of synthetic supplemental antioxidants, such as N-acetylcysteine or bardoxolone methyl, as well as of natural supplemental antioxidants, such as Vitamins C and E, sulforaphane, and others. Ongoing advances are being made in understanding the pathways that are affected and the mechanisms of action of supplemental antioxidants. More recently, however, studies have revealed a ‘dark side’ to some uses of supplemental antioxidants, wherein their protective benefits might be hijacked by oxidatively susceptible cancer cells, their activities might blunt endogenous defenses, or their metabolism might detrimentally increase stress on already stressed systems. Accordingly, comprehensive studies of the cancer genome have revealed that mutations that activate the endogenous oxidative stress response are selected in multiple types of cancer. This Special Issue aims to present papers that address the basic biology of cellular redox homeostasis and papers that provide a diverse balanced presentation of both the beneficial and detrimental impacts that antioxidant supplements can have in the context of disease states. The editors of this Special Issue welcome submissions of primary research papers, timely reviews, and visionary perspective or retrospective analyses within this domain.
Prof. Dr. Edward E. Schmidt
Prof. Dr. Hun-Taeg Chung
Prof. Dr. Volkan Sayin
Guest Editors
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