Melatonin and Related Compounds: Antioxidant and Anti-inflammatory Actions
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".
Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 58059
Special Issue Editor
Special Issue Information
Dear Colleagues,
Melatonin is synthesised endogenously in many cells and can also be administered exogenously. It has profound antioxidant activity, reacting with both oxygen- and nitrogen-derived reactive species, and, in addition, its metabolites and reaction products are also antioxidants. Melatonin scavenges hydrogen peroxide, augments endogenous antioxidant pathways, and decreases nitric oxide production. Highest levels in the cell are found in mitochondria after exogenous administration and it prevents mitochondrial dysfunction, energy failure, and apoptosis. It also ameliorates inflammatory cytokine release in cells and in animal models of oxidative injury. As such, it has numerous therapeutic possibilities. This Special Issue invites articles encompassing the antioxidant and inflammatory actions and relevant mechanistic pathways of melatonin and related compounds across the range of experimental approaches, including molecular, pre-clinical, and translational studies.
Prof. Dr. Helen Galley
Guest Editor
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Keywords
- melatonin
- oxidative stress
- antioxidant
- inflammation
- translational research
- experimental medicine
- mitochondria