The Role of Peroxiredoxins in Antioxidant Defense and Redox Signaling
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Antioxidant Enzyme Systems".
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 7920
Special Issue Editor
Special Issue Information
Dear Colleagues,
Peroxiredoxins have emerged as key players in multiple facets of antioxidant protection and redox signaling, with important implications for human health. Recent research has highlighted their roles in a wide range of physiological and pathological processes, such as tumor progression and resistance, inflammation, aging, apoptosis, circadian metabolic rhythmicity, mitosis, spindle assembly, and DNA replication fidelity. However, numerous questions about their mechanisms of action and how these relate to structural features remain open. To name but a few: What structural features determine peroxiredoxin's catalytic efficiency and hyperoxidation resistance? What determines the specificity of their interactions with their numerous interactors? How is their activity regulated by covalent modifications, and what is the role of this regulation in the physiological context? Are redox relays the paradigmatic mechanism for transducing hydrogen peroxide signals? Does the operation of peroxiredoxin-mediated redox relays require scaffold proteins, and why? How do peroxiredoxins influence cells’ resistance to hydrogen peroxide? What determines their beneficial versus deleterious effects on cancer?
This Special Issue will welcome reviews and original research articles addressing these and other exciting questions regarding peroxiredoxin’s structural, biophysical, and kinetic properties, novel specific inhibitors and research methods, their mechanisms of action in vivo, and their role in human health.
Dr. Armindo Salvador
Guest Editor
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Keywords
- peroxiredoxins
- thiol redox systems
- redox signaling
- antioxidant protection
- hydrogen peroxide
- redox relays
- redox biology
- holdases
- redox medicine
- oxidative stress
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