Oxidative Stress in Preterm Infants
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: closed (29 February 2020) | Viewed by 4400
Special Issue Editor
Interests: pediatrics; intensive care; oxidative stress; antioxidants
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress is implicated in the pathogenesis of several pathologic conditions of the preterm newborn, commonly referred to as “oxygen radical diseases of neonatology” to underline the crucial role of oxidative stress in this wide range of neonatal morbidities. Advances in neonatal care, including resuscitation and ventilation support technology, have seen increased survival rates among premature neonates and a concomitant detection in the incidence of these free radicals-related diseases.
In order to counteract free radicals damage, many strategies to augment antioxidant status in preterm infants have been proposed, and several medications have been tested with mixed results. Melatonin is both a potent free radical scavenger and a broad-spectrum antioxidant. It also possesses the capability to modulate inflammation and increases mitochondrial biogenesis. Melatonin has an excellent biosafety profile and easily crosses the placenta and blood–brain barrier; therefore, due to its wide spectrum of properties, melatonin would appear to be a potentially beneficial molecule for therapeutic uses in the management of neonates with oxidative stress-related disorders. Several studies have tested the efficacy of melatonin in diseases of newborns such as chronic lung disease, perinatal brain injury, necrotizing enterocolitis, and retinopathy of prematurity, giving promising results.
We invite you to submit your latest research findings, both in vitro and in vivo studies, or a review article to this Special Issue, which will bring together current research concerning oxidative stress in preterm infants and the action that antioxidant therapies, such as melatonin, can play to counteract this oxidative damage.
We look forward to your contribution.
Prof. Dr. Eloisa Gitto
Guest Editor
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Keywords
- Oxidative stress
- Prematurity
- Melatonin
- Neonatal intensive care
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