Redox Active Metals and Metabolism
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 8723
Special Issue Editors
Interests: metallomics; metabolomics; systems biology; oxidative stress; neurodevelopment; environmental exposures; mitochondria; maternal–fetal axis; developmental disorders
Interests: metal mixtures; immunology; autoimmunity; environmental health; community-engaged research and education
Special Issue Information
Dear Colleagues,
Redox active metals perform critical functions through regulatory, catalytic, and signaling roles. They are involved in many physiological processes such as defense against infectious agents; cellular signaling pathways, as cofactors for enzyme regulation; in redox signaling; and as structural components. Conversely, at high concentrations, redox active metals can be mediators of damage to biomolecules involving DNA, redox proteins, lipids, and metabolites.
Disturbed redox active metal homeostasis is implicated in the pathogenesis of multiple diseases that are not limited to amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, Parkinson’s disease, ischemia heart disease, rheumatoid arthritis, cancer, diabetes, and inherited metabolic abnormalities. These diseases are governed by underlying metabolic and redox dysfunction that define the progression and or origin of disease. It is therefore critical to understand the molecular interface between redox active metals and metabolism in exposure, development, nutrition, health, immunity, aging, disease, and treatment strategies.
The aim of this Issue is to bring together cutting-edge research and new insights concerning the activity, control, and detection of redox active metals in the regulation of cell systems in physiological processes and pathological conditions. Experimental studies in humans and human relevant models, animal models, and in vitro studies are welcome. Review articles that describe new mechanisms; methodologies; modes of action; compartmental signaling events; systems biology; and omics approaches related to redox active metals, oxidative stress, and metabolism can also be submitted.
We look forward to your contributions!
Dr. Jolyn Fernandes
Dr. Esther O. Erdei
Guest Editors
Manuscript Submission Information
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Keywords
- Metals
- Redox signaling
- Metabolism
- Antioxidants
- Systems biology
- Development
- Nutrition
- Toxicology
- Immunology
- Omics
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