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Applied Sciences
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Extraction, Analysis and Applications of Bioactive Compounds in Food
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Extraction, Analysis and Applications of Bioactive Compounds in Food

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Food Science and Technology".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 1536

Special Issue Editors

Dr. Tomasz Cebulak

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Guest Editor
Department of Food Technology and Human Nutrition, Institute of Food Technology and Nutrition, College of Natural Sciences, University of Rzeszów, 35-601 Rzeszów, Poland
Interests: functional foods; antioxidants in foods; polyphenols; impact of stress factors on the quality of fruit and vegetables
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Elvyra Jariené

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Guest Editor
Department of Plant Biology and Food Sciences, Vytautas Magnus University Agriculture Academy, 44001 Kaunas, Lithuania
Interests: food chemistry; plant raw materials; functional foods; biologically active substances in foods; organic farming; instrumental and sensory analytical methods of foods
Dr. Małgorzata Stryjecka

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Guest Editor
Institute of Human Nutrition and Agriculture, State School of Higher Education Chełm, 22-100 Chełm, Poland
Interests: biochemistry; microbiology; food analysis; oils; honeys
Special Issues, Collections and Topics in MDPI journals
Dr. Piotr Boruszewski

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Guest Editor
Institute of Wood Sciences and Furniture, Warsaw University of Life Sciences—SGGW, 159 Nowoursynowska St., 02-776 Warsaw, Poland
Interests: biochemistry; microbiology; plant extracts in wood protection; antibacterial and antifungal properties of extracts; organic compound analyst

Special Issue Information

Dear Colleagues,

Nature, and especially the richness that the plant world offers, draws society's attention to the search for biologically active natural substances with the possibility of their use in the food, pharmaceutical, and cosmetics industries. A wide range of raw materials, including fruits, vegetables, herbs, and spices, are currently the subject of numerous research studies aiming to obtain active phytochemicals. The forms of these substances are usually liquid, water, or water–alcoholic extracts or powders obtained from these extracts by drying using various techniques. The biological activity of plant tissue extracts depends on many biotic and abiotic factors affecting living plant cells to stimulate the synthesis of secondary metabolites, as well as extraction techniques. Another important research factor is the limitation of fluctuations in phytochemicals resulting from the extraction and fixation processes of extracts using various techniques. Therefore, the exploration of the research space related to extracts is in constant development.

The aim of this Special Issue is to promote recent and significant contributions to research on extraction techniques and extracts from natural products, both chemically and biologically. Therefore, we strongly encourage you to contribute to our current Special Issue, titled “Extraction, Analysis and Applications of Bioactive Compounds in Food”. Original scientific articles, short communications, and focus reviews are welcome to be submitted to this Special Issue.

Dr. Tomasz Cebulak
Prof. Dr. Elvyra Jariené
Dr. Małgorzata Stryjecka
Dr. Piotr Boruszewski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fruits
  • vegetables
  • spices
  • herbs
  • extraction techniques
  • polyphenols
  • biological activity
  • polyphenols
  • antioxidants

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

15 pages, 8278 KiB  
Article
Optimization of Ethanol Concentration and Wetting Time for Industrial-Scale Production of Ipomoea batatas L. Leaf Extract
by Cokorda Istri Sri Arisanti, Ida Musfiroh, I Made Agus Gelgel Wirasuta, Nur Kusaira Khairul Ikram and Muchtaridi Muchtaridi
Appl. Sci. 2025, 15(8), 4299; https://doi.org/10.3390/app15084299 - 13 Apr 2025
Viewed by 237
Abstract
Extraction is one of the most important phases in the food, pharmaceutical, and nutraceutical industries, as it enables the isolation of valuable compounds from raw materials. Ipomoea batatas L. leaf extract has anti-diabetic qualities due to anthocyanidins, flavonols, flavanones, and phenolic acids. The [...] Read more.
Extraction is one of the most important phases in the food, pharmaceutical, and nutraceutical industries, as it enables the isolation of valuable compounds from raw materials. Ipomoea batatas L. leaf extract has anti-diabetic qualities due to anthocyanidins, flavonols, flavanones, and phenolic acids. The goal of this study is to maximize extraction on a production scale with total flavonoids and fingerprint profiles that closely resemble standardized extracts. In this study, extraction was performed using the percolator method with optimization parameters, including ethanol concentration (40, 50, 60, and 70%) and wetting time (0.5, 3, and 24 h). Quality control in extraction was assessed through the total flavonoids and fingerprint analysis. TLC was used to determine the fingerprints of Ipomoea batatas L. leaf extract, followed by multivariate analysis. Using 60% ethanol and 3 h of wetting time produced total flavonoids of 19.86 ± 0.2 mg quercetin/g and a fingerprint close to the control with a similarity of 94.87%. Ethanol concentration and wetting time are critical parameters in Ipomoea batatas L. extraction. Quality control through total flavonoid determination and fingerprint analysis during the extraction process provides a standardized approach to maintain the quality, safety, and efficacy of Ipomoea batatas L. natural products. Full article
(This article belongs to the Special Issue Extraction, Analysis and Applications of Bioactive Compounds in Food)
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18 pages, 1224 KiB  
Article
Immune Modulation Effect of Administration of Rice Bran Extract with Increased Solubility Fermented by Lentinus edodes UBC-V88 in Cyclophosphamide-Treated Mice Model
by Gi-Jung Kim, Yelim Jang, Ji-Yoon Hong, Kyoung-Tae Kwon, Dae-Weon Kim, Dae-Jung Kang, Sung-Joo Hwang, Jung-Yun Lee, Emmanouil Apostolidis and Young-In Kwon
Appl. Sci. 2025, 15(2), 876; https://doi.org/10.3390/app15020876 - 17 Jan 2025
Viewed by 670
Abstract
There is a global and increasing demand for natural ingredients that support the human immune response. In this study, the immunomodulatory effect and mechanism of action of rice bran extract fermented by Lentinus edodes was investigated. The potential immunomodulatory effect of fermented rice [...] Read more.
There is a global and increasing demand for natural ingredients that support the human immune response. In this study, the immunomodulatory effect and mechanism of action of rice bran extract fermented by Lentinus edodes was investigated. The potential immunomodulatory effect of fermented rice bran (FRB) and processed rice bran (RB) was evaluated using male BALB/c mice whose immunity was lowered by Cyclophosphamide (CY). The changes in the weight of the thymus and the spleen, immunoglobulins, and cytokine expressions were measured as biomarkers of immunomodulating potential after 14 days of oral administration of FRB and RB (0.5 g/kg-body weight (b.w.), respectively). The FRB and RB groups treated with CY resulted in increased weight of the thymus (1.73 ± 0.40 and 1.45 ± 0.43 mg/g-b.w., respectively) compared to the CY-treated control group (1.05 ± 0.36 mg/g-b.w.). The levels of the immunoglobulin (Ig) G in the group treated with FRB (21.98 ± 2.17, p < 0.01) were significantly increased when compared to the RB group (18.48 ± 1.52 μg/mL, p < 0.01). The expression of serum cytokines, including IL-1α (p < 0.05), IL-2 (p < 0.05), IL-6 (p < 0.001), IL-12 p70 (p < 0.01), IFN-γ (p < 0.01), and TNF-α (p < 0.01) were also significantly increased by the administration of FRB (0.5 g/kg-b.w.). Similarly, the expression of spleen cytokines, including IL-1α (p < 0.05), IL-2 (p < 0.05), IFN-γ (p < 0.01), and TNF-α (p < 0.05), was also significantly increased in the group receiving the FRB (0.5 g/kg-b.w.). The natural killer cell (NK) cell activities at a 1:25 ratio of YAC-1 cells to splenocytes were significantly increased in positive control red ginseng extract 0.5 g/kg (38.64 ± 2.13%, p < 0.05), FRB (34.85 ± 3.45%, p < 0.05), and RB (25.00 ± 4.18%), compared to that of negative control CY group (12.67 ± 3.23%). These results suggest that FRB administration could stimulate the innate immune system by increasing the expression of cytokines in splenocytes and serum, especially IFN-γ, IL-2, and IL-12 (p70), which are associated with TNF-α and NK cell activities. The above results could provide the biochemical rationale to further evaluate the use of FRB for immunomodulatory applications. Full article
(This article belongs to the Special Issue Extraction, Analysis and Applications of Bioactive Compounds in Food)
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