Innovations in Regenerative Therapy: Cell and Cell-Free Approaches

Dear Colleagues,

Regenerative therapy represents a groundbreaking field in medicine focused on repairing, replacing, or regenerating damaged tissues and organs. This Special Issue highlights the latest innovations, emphasizing cell-based and cell-free approaches. Key areas include mesenchymal stem cells (MSCs), exosomes, extracellular vesicles, and bio nanovesicles, targeting conditions such as wounds, ischemia, hair growth issues, brain injuries, and degenerative diseases. Cell-based therapies, particularly those using MSCs, are central to regenerative medicine. MSCs, sourced from bone marrow, adipose tissue, and other origins, can differentiate into multiple cell types and have immunomodulatory effects. They show promise in treating wounds, ischemic injuries, and degenerative diseases, with ongoing research into their application for cardiac repair post-myocardial infarction and enhancing hair growth and skin regeneration. Cell-free therapies, using bioactive molecules from cells, present a promising alternative. Exosomes, a type of extracellular vesicle, facilitate intercellular communication and tissue repair. They show potential in treating neurodegenerative diseases, enhancing wound healing, and supporting cardiac repair after ischemic events. Bio nanovesicles, engineered for precise therapeutic delivery, enhance treatment effectiveness in wound healing, ischemia, hair growth, and brain repair. Both cell-based and cell-free therapies accelerate wound healing, with MSCs promoting tissue repair and exosomes modulating the wound environment. Regenerative therapies for ischemic heart disease promote angiogenesis and improve cardiac function. Investigations into hair loss treatments reveal MSCs and exosomes can regenerate hair follicles. Neuroregenerative therapies using MSCs and exosomes show promise in treating brain injuries and neurodegenerative diseases. MSCs and exosomes could also regenerate cartilage and neural tissues in chronic degenerative diseases like osteoarthritis. Challenges include ensuring the safety, efficacy, and scalability of these treatments. Future research will likely combine cell-based and cell-free approaches for synergistic effects and develop personalized therapies tailored to individual genetic and molecular profiles. This Special Issue aims to foster collaboration and inspire further research, ultimately advancing the goal of restoring normal tissue function and improving patient quality of life.

Dr. Prakash Gangadaran
Guest Editor

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• cell-based therapies
• MSCs
• exosome
• extracellular vesicles
• bio nanovesicles
• wound
• ischemia
• hair growth
• brain
• degenerative diseases