Research Progress on Parasitic and Microbial Infection and Immunity

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Infection Biology".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 1156

Special Issue Editors


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Guest Editor
Department of Entomology, Texas A&M University, College Station, TX 77843, USA
Interests: medical entomology; tick biology; parasitology; vector-borne diseases
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Entomology, University of Wisconsin-Madison, Madison, WI 53706, USA
Interests: wound healing responses; innate immune responses; skin immunity; tick feeding; tick mediated pathogen transmission
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Molecular and cellular players involved in the orchestration of the immune responses that lead to protection during infection still need to be investigated. Likewise, pathogens, including bacteria, viruses and parasites, have developed different strategies to evade or manipulate the host’s immune response and secure a successful infection. Mechanisms such as capsule formation, antigenic variation, secretion of toxins, and other molecules facilitate pathogen entry and establishment and can lead to pathogenic escape from defensive host responses, thus allowing pathogens to infect their host and complete their life cycle. Yet, the host maintains homeostasis by activating complex immune pathways that involve innate and adaptive responses. These pathways result in the production and release of different molecular compounds that can block the entry of pathogens or lead to their killing. In this Special Issue, we are pleased to invite you to submit investigations, research articles and reviews on the molecular mechanisms used by parasites, viruses, and bacteria to escape host immune responses and aid in the infection process. We also invite papers describing in vivo and in vitro studies that investigate how the host fights back in the race against infecting pathogens.

We look forward to receiving your contributions.

Dr. Julia González
Dr. Adela Oliva Chávez
Guest Editors

Manuscript Submission Information

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Keywords

  • host
  • pathway
  • defense
  • innate immune responses
  • adaptive immune responses
  • pathogenicity
  • immune signalling
  • bacterial infection
  • viral infection
  • parasitic infection

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Published Papers (1 paper)

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Research

12 pages, 1503 KiB  
Article
Padina Minor Extract Confers Resistance against Candida Albicans Infection: Evaluation in a Zebrafish Model
by Chang-Cheng Wu, De-Sing Ding, Yi-Hao Lo, Chieh-Yu Pan and Zhi-Hong Wen
Biology 2024, 13(6), 384; https://doi.org/10.3390/biology13060384 - 27 May 2024
Viewed by 748
Abstract
Padina minor is a seaweed rich in polysaccharides often used in food, feed, fertilizers, and antibacterial drugs. This study is the first to evaluate the effect of feeding zebrafish with Padina minor extract on preventing and treating C. albicans infections. This study evaluated [...] Read more.
Padina minor is a seaweed rich in polysaccharides often used in food, feed, fertilizers, and antibacterial drugs. This study is the first to evaluate the effect of feeding zebrafish with Padina minor extract on preventing and treating C. albicans infections. This study evaluated the growth, survival, and disease resistance effects of P. minor extract on zebrafish. The fish were divided into four groups: three groups treated with 1%, 5%, or 10% P. minor extract and one untreated group (c, control). Subsequently, we analyzed how the extract affected the immune function of zebrafish infected with C. albicans. Based on the lethal concentration (LC50) calculated in the first stage, 1% was used as the effective therapeutic concentration. The results showed that the growth rate of the 1% feed group was the best, and no significant difference in survival rates between the four groups was observed. Feeding with 1% P. minor extract downregulated the expression of key inflammatory genes like tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), and IL-10, effectively preventing and treating C. albicans infections in zebrafish. This study is a preliminary evaluation of the therapeutic efficacy of P. minor extracts against C. albicans. Full article
(This article belongs to the Special Issue Research Progress on Parasitic and Microbial Infection and Immunity)
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