Kinase Receptor Signaling in the Inflammatory Response of Cardiac Diseases

Dear Colleagues,

Inflammation is a natural and necessary process through which the immune system responds to infection, cell stress, and tissue damage. This process is characterized by vascular dilation, enhanced permeability of capillaries, increased blood flow, and leukocyte recruitment. A typical inflammatory response consists of four components: inflammatory inducers, the sensors that detect them, the inflammatory mediators induced by the sensors, and the target tissues that are affected by the inflammatory mediators. Each component comes in multiple forms and their combinations function in distinct inflammatory pathways. The type of pathway induced under given conditions depends on the nature of the inflammatory trigger. Inflammation is a key player in many cardiovascular diseases. It has been linked to the pathogenesis of acute coronary syndromes, reperfusion injury to ischemic myocardium, restenosis after angioplasty failure of cardiac transplant, and chronic heart failure. In response to different conditions as well as cardiovascular risk factors (such as hypertension, hyperlipidemia, hyperglycemia, and smoking) and stress-related conditions (i.e., depression, and anxiety) the heart acts as an “immune” organ by activating complex inflammatory and reparative cascades that lead to the resolution of inflammation.

Dr. Maria Rosaria Rusciano
Dr. Elena Ciaglia
Dr. Paola Di Pietro
Guest Editors

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