Submit to Biology Review for Biology Propose a Special Issue

Journal Browser

► Journal Browser

Recent Advances in the Use of Microwaves in Cancer Treatments

Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cancer Biology".

Deadline for manuscript submissions: closed (7 August 2021) | Viewed by 9435

Share This Special Issue

Special Issue Editors

Dr. Jacqueline M. R. Bélanger

E-Mail Website
Guest Editor

Atlantic Cancer Research Institute, 35 Providence Street, Moncton, NB E1C 8X3, Canada
Interests: microwave; tumour ablation; new tools for cancer detection and treatment
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. J. R. Jocelyn Paré

E-Mail Website
Guest Editor

1. Atlantic Cancer Research Institute, Providence St, Moncton, NB E1C 8X3, Canada
2. Department of Chemistry, McGill University, 845 Sherbrooke St W, Montreal, QC H3A 0G4, Canada
Interests: advanced energy systems for cancer treatment; intelligent microwave antennas for interventional radiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue of Biology aims at providing a snapshot of the current status of the use of microwaves in interventional radiology with a focus on cancer treatment. This objective is ambitious because advances in microwave-assisted cancer treatment are intimately interlaced with the development of other peripheral technologies. For example, advances in guidance technologies play a significant role in enhancing the precision of microwave interventions. Automation and robotics-based advances are also emerging and will no doubt have a significant impact on the technology.

It is also necessary to capture some recent promising trends such as combinatorial procedures where microwaves are applied simultaneously or in series with drugs aiming at accelerating post-treatment healing or providing additional prolonged protection against the resurgence of the disease. It is also timely to provide some insight into the medium- to long-term impact of these procedures on patients.

The broader objective is to gather under a single issue a timely yet concise overview of the state of the art in the use of microwaves in interventional radiology and associated medical treatments.

Dr. Jacqueline M. R. Bélanger
Prof. Dr. J. R. Jocelyn Paré
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Microwave ablation
Microwave-assisted chemical ablation
RF ablation
Guidance technologies in interventional radiology
Use of microwaves in combinatorial treatment
Automation of microwave-assisted radiological interventions

Published Papers (3 papers)

Download All Papers

Research

Jump to: Review

12 pages, 1194 KiB

Open AccessArticle

Numerical Optimization of an Open-Ended Coaxial Slot Applicator for the Detection and Microwave Ablation of Tumors

by Carolin Hessinger, Martin Schüßler, Sabrina Klos, Markus Kochanek and Rolf Jakoby

Biology 2021, 10(9), 914; https://doi.org/10.3390/biology10090914 - 14 Sep 2021

Cited by 4 | Viewed by 2111

Abstract

A multiobjective optimization method for a dual-mode microwave applicator is proposed. Dual-modality means that microwaves are used apart from the treatment, and also for the monitoring of the microwave ablation intervention. (1) The use of computational models to develop and improve microwave ablation applicator geometries is essential for further advances in this field. (2) Numerical electromagnetic–thermal coupled simulation models are used to analyze the performance of the dual-mode applicator in liver tissue; the sensitivity evaluation of the dual-mode applicator’s sensing mode constrains the set of optimal solutions. (3) Three Pareto-optimal design parameter sets are derived that are optimal in terms of applicator efficiency as well as volume and sphericity of the ablation zone. The resulting designs of the dual-mode applicator provide a suitable sensitivity to distinguish between healthy and tumorous liver tissue. (4) The optimized designs are presented and numerically characterized. An improvement on the performance of previously proposed dual-mode applicator designs is achieved. The multiphysical simulation model of electromagnetic and thermal properties of the applicator is applicable for future comprehensive design procedures. Full article

(This article belongs to the Special Issue Recent Advances in the Use of Microwaves in Cancer Treatments)

► Show Figures

Figure 1

9 pages, 1148 KiB

Open AccessArticle

Lung Thermal Ablation: Comparison between an Augmented Reality Computed Tomography (CT) 3D Navigation System (SIRIO) and Standard CT-Guided Technique

by Rosario Francesco Grasso, Flavio Andresciani, Carlo Altomare, Giuseppina Pacella, Gennaro Castiello, Massimiliano Carassiti, Carlo Cosimo Quattrocchi, Eliodoro Faiella and Bruno Beomonte Zobel

Biology 2021, 10(7), 646; https://doi.org/10.3390/biology10070646 - 11 Jul 2021

Cited by 3 | Viewed by 2101

Abstract

(1) Background: The aim of this retrospective study is to assess safety and efficacy of lung radiofrequency (RFA) and microwave ablation (MWA) using an augmented reality computed tomography (CT) navigation system (SIRIO) and to compare it with the standard CT-guided technique. (2) Methods: Lung RFA and MWA were performed with an augmented reality CT 3D navigation system (SIRIO) in 52 patients. A comparison was then performed with a group of 49 patients undergoing the standard CT-guided technique. All the procedures were divided into four groups based on the lesion diameter (>2 cm or ≤2 cm), and procedural time, the number of CT scans, radiation dose administered, and complications rate were evaluated. Technical success was defined as the presence of a “ground glass” area completely covering the target lesion at the immediate post-procedural CT. (3) Results: Full technical success was achieved in all treated malignant lesions for all the considered groups. SIRIO-guided lung thermo-ablations (LTA) displayed a significant decrease in the number of CT scans, procedure time, and patients’ radiation exposure (p < 0.001). This also resulted in a dosage reduction in hypnotics and opioids administrated for sedation during LTA. No significant differences were observed between the SIRIO and non-SIRIO group in terms of complications incidence. (4) Conclusions: SIRIO is an efficient tool to perform CT-guided LTA, displaying a significant reduction (p < 0.001) in the number of required CT scans, procedure time, and patients’ radiation exposure. Full article

(This article belongs to the Special Issue Recent Advances in the Use of Microwaves in Cancer Treatments)

► Show Figures

Figure 1

Review

Jump to: Research

18 pages, 6903 KiB

Open AccessReview

Stereotactic Thermal Ablation of Liver Tumors: 3D Planning, Multiple Needle Approach, and Intraprocedural Image Fusion Are the Key to Success—A Narrative Review

by Gregor Laimer, Peter Schullian and Reto Bale

Biology 2021, 10(7), 644; https://doi.org/10.3390/biology10070644 - 10 Jul 2021

Cited by 16 | Viewed by 4382

Abstract

Thermal ablation is an emerging, potentially curative approach in treating primary and metastatic liver cancer. Different technologies are available, with radiofrequency ablation (RFA) and microwave ablation (MWA) being the most widely used. Regardless of the technique, destruction of the entire tumor, including an adequate safety margin, is key. In conventional single-probe US- or CT-guided thermal ablation, the creation of such large necrosis zones is often hampered by technical limitations, especially for large tumors (i.e., >2–3 cm). These limitations have been overcome by stereotactic RFA (SRFA): a multiple needle approach with 3D treatment planning and precise stereotactic needle placement combined with intraprocedural image fusion of pre- and post-interventional CT scans for verification of treatment success. With these sophisticated tools and advanced techniques, the spectrum of locally curable liver malignancies can be dramatically increased. Thus, we strongly believe that stereotactic thermal ablation can become a cornerstone in the treatment of liver malignancies, as it offers all the benefits of a minimally invasive method while providing oncological outcomes comparable to surgery. This article provides an overview of current stereotactic techniques for thermal ablation, summarizes the available clinical evidence for this approach, and discusses its advantages. Full article

(This article belongs to the Special Issue Recent Advances in the Use of Microwaves in Cancer Treatments)

► Show Figures