Advances in Systems Metabolic Engineering for Biochemicals Production
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Microbiology".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 218
Special Issue Editor
Special Issue Information
Dear Colleagues,
Due to the depletion of fossil fuels and the concern of climate change, the production of green chemicals via engineering microbes and bioprocesses has been considered an available way to completely transform the traditional production mode, which will lead to new economic growth and reinvent carbon-based civilization. With the development of synthetic biology and systems metabolic engineering, a variety of microbes have been modified as hosts including Escherichia coli, yeast, and some filamentous fungi. Coupled with the optimization of bioprocesses, different kinds of biochemicals have been successfully produced by engineered microbes. Although the productivity of partial biochemicals has achieved a preferable level, it still cannot meet the needs of industrial production. Some limitations need to be further addressed in the production of biochemicals by engineered microbes such as the high production cost, the excessive by-product accumulation, the low conversion efficiency of substrates, the poor tolerance of hosts, and so on. Therefore, more effective strategies should be developed that are focused on these issues. This Special Issue aims to highlight the findings in the field of biochemical production via systems metabolic engineering of microbes, which will contribute to the promotion of the industrial production of biochemicals.
Topics of interest for this issue include, but are not limited to, the following: the biosynthesis of new chemicals, the reconstruction of biosynthesis pathways, the development of new hosts, novel metabolic engineering strategies and products, extraction techniques for biochemicals, the improvement in the fermentation process, the conversion of inexpensive raw materials, and the analysis of metabolic mechanisms. This Special Issue welcomes comprehensive reviews, research articles, and short communications on novel findings related to these topics. I look forward to receiving your contributions.
Dr. Huan Liu
Guest Editor
Manuscript Submission Information
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Keywords
- systems metabolic engineering
- biochemicals
- synthetic biology
- bioprocess engineering
- pathway modification
- strain development
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