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Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Soil Microbe–Microbivore–Plant Interactions Related to Soil Carbon Cycling in Terrestrial Ecosystems

edited by Xuechen Yang and Linlin Mei

submission deadline 31 Jan 2027 | 3 articles | Viewed by 1541 | Submission Open

Keywords: carbon sequestration; carbon decomposition; soil microorganisms; soil microbivores; stress physiology; climate change; human activities

(This special issue belongs to the Section Microbiology)

AI-Driven Innovations in NanoBioTech: From Molecular Mechanisms to Engineering Applications

edited by

Yu Ding

submission deadline 31 Jan 2027 | 2 articles | Viewed by 780 | Submission Open

Keywords: AI; AlphaFold; RFdiffusion; NanoBioTech; translational biotechnology; protein design; bioprocess optimization; nanomedicine; synthetic biology; multi-omics; precision health

(This special issue belongs to the Section Biotechnology)

Autism Spectrum Disorder: From Bench to Molecular Mechanisms

edited by

Dario Siniscalco

submission deadline 31 Jan 2027 | Viewed by 443 | Submission Open

Keywords: autism spectrum disorder ; epigenetics ; synaptic circuitry ; gene regulation ; microbiome

(This special issue belongs to the Section Neuroscience)

Extracellular Vesicles in Cardiovascular and Metabolic Diseases

edited by

Jiong-Wei Wang

submission deadline 31 Jan 2027 | Viewed by 331 | Submission Open

Keywords: atherosclerosis; myocardial infarction; heart failure; fatty liver disease; diabetes; extracellular vesicles; nanoparticles; nanomedicine; imaging; therapeutics

(This special issue belongs to the Section Medical Biology)

Cryopreservation of Embryos, Gametes and Ovarian Tissue

edited by

Marcelo Borges Cavalcante

submission deadline 31 Jan 2027 | Viewed by 294 | Submission Open

Keywords: cryopreservation; vitrification; embryo freezing; oocyte cryopreservation; sperm freezing; ovarian tissue cryopreservation; fertility preservation; oncofertility; cryobiology; assisted reproductive technology

The Role of Small Airway Dysfunction in Airway Diseases

edited by

Warawut Chaiwong

, Athavudh Deesomchok and Chaicharn Pothirat

submission deadline 31 Jan 2027 | Viewed by 293 | Submission Open

Keywords: small airway dysfunction; airway diseases; molecular mechanisms; airway inflammation; biomarkers; lung physiology; imaging techniques; disease phenotypes; airway remodeling

(This special issue belongs to the Section Medical Biology)

Beta Cells and Diabetes

edited by Fernanda Ortis

submission deadline 31 Jan 2027 | Viewed by 251 | Submission Open

Keywords: pancreatic beta cell; diabetes; insulin secretion; cellular stress response; beta cell plasticity; islet inflamma-tion

(This special issue belongs to the Section Cell Biology)

Protein Structure–Function Relationship and Its Role in the Cell

edited by Jayaraman Seetharaman

submission deadline 31 Jan 2027 | Viewed by 238 | Submission Open

Keywords: protein structure–function relationship; structural biology (X-Ray, NMR, Cryo-EM); conformational dynamics; allosteric regulation; protein–protein and protein–ligand interactions; post-translational modifications and computational biology

(This special issue belongs to the Section Cell Biology)

Molecular Biomarkers and Epigenetic Regulation in Cardiothoracic Diseases

edited by Carolyn Glass

submission deadline 31 Jan 2027 | Viewed by 199 | Submission Open

Keywords: epigenetics; cancer; interstitial lung disease; cardiovascular disease; computational pathology; artificial intelligence; machine learning; aging/senescence

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Molecular Pathways to β-Cell Dysfunction in Diabetes

edited by

Seiho Nagafuchi

submission deadline 31 Jan 2027 | Viewed by 181 | Submission Open

Keywords: diabetes; T1D; T2D; insulin; glucose; pancreas; β-cell signaling pathway; receptor

(This special issue belongs to the Section Cell Biology)

Advances in Wildlife Conservation and Habitat Management in the Anthropocene, Second Edition

edited by

Yiannis G. Zevgolis

and

Panayiotis G. Dimitrakopoulos

submission deadline 31 Jan 2027 | Viewed by 176 | Submission Open

Keywords: innovative technologies; advanced monitoring techniques; habitat suitability modeling; species distribution modeling; climate change scenarios; anthropogenic, biotic, and abiotic stressors; environmental impact assessments; invasive species management; disease outbreak impacts; long-term ecological monitoring; protected area effectiveness; keystone species conservation; threatened species; adaptive conservation strategies; conservation planning; wildlife conservation; habitat management

(This special issue belongs to the Section Ecology)

New Insights into Crop Production, Management, and Ecophysiology

edited by Hada Wuriyanghan,

Fang Yan

and Gongfu Shi

submission deadline 31 Jan 2027 | Viewed by 123 | Submission Open

Keywords: crop improvement; disease management; plants in ecosystem; plant physiology; plant-pathogen interac-tions; plant-plant interactions; plant signaling and behavior; crop adaptation

(This special issue belongs to the Section Plant Science)

Endothelial Cell Biology in Health and Pathological Conditions

edited by Constantinos Marios Mikelis

submission deadline 31 Jan 2027 | Viewed by 121 | Submission Open

Keywords: endothelial cells; endothelial biology; signalling; vascular pathophysiology; cell-to-cell communication; endothelial heterogeneity

(This special issue belongs to the Section Cell Biology)

Emerging Hallmarks in Cancer Immunology

edited by

Ana Paula Silva de Azevedo-Santos

submission deadline 1 Feb 2027 | 1 articles | Viewed by 2010 | Submission Open

Keywords: immune vigilance; cancer immunoediting; tumor microenvironment; immunotherapy

(This special issue belongs to the Section Immunology)

Cell Self-Destruction (Programmed Cell Death), Immunonutrition and Metabolism (2nd Edition)

edited by

Vishwanath Venketaraman

submission deadline 15 Feb 2027 | 3 articles | Viewed by 11592 | Submission Open

Keywords: autoimmunity; cell self-destruction; infection; inflammation; immunonutrition; lipotoxicity; metabolism; programmed cell death

(This special issue belongs to the Section Immunology)

Synaptic Function and Energy Use

edited by

Gen Ohtsuki

submission deadline 15 Feb 2027 | 1 articles | Viewed by 3092 | Submission Open

Keywords: presynapse; postsynapse; ATP; mitochondria; glia; pericyte; vasculature; fatty acids; ketone bodies; leptin; insulin; glucose; lactate

(This special issue belongs to the Section Neuroscience)

Young Researchers in Ecology

edited by

Panayiotis G. Dimitrakopoulos

submission deadline 28 Feb 2027 | 6 articles | Viewed by 12999 | Submission Open

Keywords: adaptations to variable environments; biodiversity; biogeography; biotic interactions (e.g., competition, predation parasitism, mutualism, amensalism, commensalism); community assembly; conservation; ecological management and restoration; ecological sustainability; ecosystem processes (productivity, decomposition, nutrient cycling); evolution; functional traits; global changes (e.g., climate change, land use change, biological invasions, nitrogen deposition); landscape ecology; life histories; physiological ecology; population dynamics; protected areas; succession; trophic levels; Afrikaans; Albanian; Amharic; Arabic; Armenian; Azerbaijani; Bengali; Bulgarian; Catalan; Croatian; Czech; Danish; Dutch; English; Estonian; Finnish; French; German; Greek; Gujarati; Haitian Creole; Hebrew; Hindi; Hungarian; Icelandic; Indonesian; Italian; Japanese; Kannada; Kazakh; Khmer; Korean; Kurdish (Kurmanji); Lao; Latvian; Lithuanian; Malagasy; Malay; Malayalam; Maltese; Maori; Marathi; Myanmar (Burmese); Nepali; Norwegian; Pashto; Persian; Polish; Portuguese; Punjabi; Romanian; Russian; Samoan; Simplified Chinese; Slovak; Slovenian; Spanish; Swedish; Tamil; Telugu; Thai; Traditional Chinese; Turkish; Ukrainian; Urdu; Vietnamese; Welsh

(This special issue belongs to the Section Ecology)

Bioavailability, Metabolism, and Health Effects of Phenolic Compounds

edited by

Davide Tagliazucchi

and Alice Cattivelli

submission deadline 28 Feb 2027 | 3 articles | Viewed by 10486 | Submission Open

Keywords: phenolic compounds; gut microbiota; metabolism; cardiovascular diseases; cancer; anti-proliferative activity; bioavailability; bioaccessibility

(This special issue belongs to the Section Biochemistry and Molecular Biology)

New Insights in Cancer Genetics—2nd Edition

edited by

Ilda Patrícia Ribeiro

, Isabel Marques Carreira and

Alberto Orfao

submission deadline 28 Feb 2027 | 3 articles | Viewed by 8459 | Submission Open

Keywords: genomic and epigenetic characterization; diagnosis and prognosis biomarkers; omics profiles; genetic and genomic signature; molecular heterogeneity; molecular targeted therapy; oncogenic signaling pathways; copy number alterations and mutational landscape; chromosome abnormalities

(This special issue belongs to the Section Cancer Biology)

RNA Biology and Roles in Diseases

edited by Nan Wu and

Sema Misir

submission deadline 28 Feb 2027 | 3 articles | Viewed by 7274 | Submission Open

Keywords: RNA biology; diseases; circRNA; mRNA; non-coding RNA

(This special issue belongs to the Section Biochemistry and Molecular Biology)

The Emerging Role of Mitochondria in Neurobiology

edited by

Filipe V. Duarte

and

Claudia Deus

submission deadline 28 Feb 2027 | 1 articles | Viewed by 6588 | Submission Open

Keywords: mitochondrial dynamics; neurodegenerative diseases; neuronal bioenergetics; synaptic function; neurogenesis; neuronal plasticity

(This special issue belongs to the Section Neuroscience)

Animal Models of Autoimmune Diseases

edited by Feng Zhu and Keqiang Chen

submission deadline 28 Feb 2027 | 4 articles | Viewed by 5101 | Submission Open

Keywords: autoimmune disease; infection; innate immunity; inflammation; cancer risk; therapeutic target; adaptive immunity

(This special issue belongs to the Section Physiology)

Hope for the Forgotten: Tackling Endemic Parasitic Diseases with New Tools and Ideas

edited by Cecilia Perez Brandán

submission deadline 28 Feb 2027 | 3 articles | Viewed by 4065 | Submission Open

Keywords: parasitic diseases; neglected tropical diseases (NTDs); host–parasite interactions; virulence mechanisms; immune evasion; molecular pathogenesis; genomic adaptations; drug discovery; drug repurposing; vaccine development; diagnostic biomarkers; tropical medicine; endemic infections

(This special issue belongs to the Section Infection Biology)

The Role of Gut Microbiota in Human Metabolism and Disease

edited by

Asada Leelahavanichkul

submission deadline 28 Feb 2027 | 2 articles | Viewed by 3044 | Submission Open

Keywords: microbiota; bacteriome; fungiome; virome; cross-talk

Algal Stress Responses: Molecular and Ecological Perspectives

edited by

Chih-Ching Chung

submission deadline 28 Feb 2027 | 1 articles | Viewed by 2661 | Submission Open

Keywords: phytoplankton; stress; global changes

(This special issue belongs to the Section Ecology)

Progress in Wildlife Conservation, Management and Biological Research—2nd Edition

edited by Ana Carolina Srbek-Araujo

submission deadline 28 Feb 2027 | 4 articles | Viewed by 2183 | Submission Open

Keywords: adaptive capacity; climate change; conservation opportunities; species vulnerability; threatened species; wildlife conservation; wildlife management

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Skeletal Muscle Physiology in Health and Aging

edited by

Roberto Bonanni

submission deadline 28 Feb 2027 | 1 articles | Viewed by 726 | Submission Open

Keywords: skeletal muscle; muscle physiology; healthy; aging; nutrition; senescence; gut microbiota; crosstalk

(This special issue belongs to the Section Physiology)

Animal Models of Papillomavirus Infection and Pathogenesis

edited by

Rui Gil da Costa

submission deadline 28 Feb 2027 | 1 articles | Viewed by 680 | Submission Open

Keywords: cancer; mouse model; infection; immunology; HPV

(This special issue belongs to the Section Infection Biology)

Uncovering the Intricate Relationship Between the Human Microbiome and Chronic Diseases

edited by

Zheng Wang

submission deadline 28 Feb 2027 | Viewed by 578 | Submission Open

Keywords: gut microbiome; oral microbiome; metabolomics; proteomics; inflammation; multi-omics; diet; cardiovascular diseases; type 2 diabetes mellitus

(This special issue belongs to the Section Medical Biology)

Metabolic Interactions Between the Gut Microbiome and Host (2nd Edition)

edited by

Weiwei Wang

and

Yun Ji

submission deadline 28 Feb 2027 | Viewed by 402 | Submission Open

Keywords: gut microbiome; host; metabolome; microbial heterogeneity; biomolecules

(This special issue belongs to the Section Microbiology)

Transcription Factors and Signaling Pathways in Tooth and Craniofacial Development

edited by Devi Atukorallaya

submission deadline 28 Feb 2027 | Viewed by 376 | Submission Open

Keywords: teeth; taste buds; facial bones and cartilage; animal models; birth defects; dental hard tissue development and mineralization; regeneration; cell signaling pathways

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Effects of Ionizing Radiation on Biomolecular Systems

edited by Antonella Bertucci

submission deadline 28 Feb 2027 | Viewed by 362 | Submission Open

Keywords: biomarkers; ionizing radiation; omics; high-throughput; dose

(This special issue belongs to the Section Biophysics)

Biological Mechanisms and Innovative Strategies for Postharvest Quality Preservation in Horticultural Crops

edited by

Yi Chen

and

Christian Chervin

submission deadline 28 Feb 2027 | Viewed by 268 | Submission Open

Keywords: postharvest biology; quality regulation; signal transduction; hormone crosstalk; metabolic reprogramming; stress physiology; transcriptional regulation; preservation mechanisms

(This special issue belongs to the Section Plant Science)

Cell Adhesion and Adaptation to Physical Cues

edited by

Kazuo Katoh

submission deadline 28 Feb 2027 | Viewed by 230 | Submission Open

Keywords: cell adhesion; signal transduction; extracellular matrix (ECM); focal adhesions; integrins; cytoskeleton; mechanosensing; cellular response

(This special issue belongs to the Section Cell Biology)

Modern Techniques in Neuropathophysiology: Mechanisms and Biological Insights

edited by

Dušan Mladenović

and

Milena Veskovic

submission deadline 28 Feb 2027 | Viewed by 209 | Submission Open

Keywords: neuropathophysiology; neuronal network remodeling; neuroinflammation; glial cells; synaptic plasticity; modern techniques; artificial intelligence; novel methodology

(This special issue belongs to the Section Neuroscience)

Animal Genetic Resources and Characterization of Populations

edited by

Antonio González Ariza

and Jose Ignacio Salgado Pardo

submission deadline 28 Feb 2027 | Viewed by 192 | Submission Open

Keywords: domestic animal genetic resources; genetic diversity conservation; population management; livestock and poultry; reproductive techniques; phenotypic characterization; indigenous genotypes; sustainable animal production systems

(This special issue belongs to the Section Genetics and Genomics)

Developmental Metabolic Programming: Early-Life Determinants of Lifelong Health and Disease

edited by

Susana P. Pereira

and

Ludgero C. Tavares

submission deadline 28 Feb 2027 | Viewed by 162 | Submission Open

Keywords: developmental metabolic programming; in utero programming; mitochondrial function; metabolic flexibility; disease risk; cardio

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Genomic Basis of Domestication and Trait Improvement in Crops

edited by

Ezio Portis

and

Matteo Martina

submission deadline 28 Feb 2027 | Viewed by 81 | Submission Open

Keywords: crop genomics; domestication; trait improvement; plant genetic resources; landraces; germplasm banks; molecular breeding; genetic diversity

(This special issue belongs to the Section Plant Science)

The Functional Morphology of Animals

edited by

Judney Cley Cavalcante

and

Bento João Da Graça Azevedo Abreu

submission deadline 1 Mar 2027 | Viewed by 276 | Submission Open

Keywords: functional morphology; animal biomechanics; evolutionary adaptation; morphological diversity; specialized structures; comparative anatomy; functional ecology; morphological evolution; functional integration; animal anatomy

(This special issue belongs to the Section Zoology)

Mechanisms of Environmental Stress Adaptation and Tolerance in Woody Plants

edited by

Antonella Gori

and Sara Beltrami

submission deadline 15 Mar 2027 | 2 articles | Viewed by 1085 | Submission Open

Keywords: woody plants; environmental stress; stress adaptation; climate change; physiological plasticity; molecular mechanisms; drought tolerance; stress signaling

(This special issue belongs to the Section Plant Science)

Plant–Pathogen Interaction (3rd Edition)

edited by

Maria Doroteia Campos

Maria do Rosário Félix

and Lénia Rodrigues

submission deadline 28 Mar 2027 | Viewed by 274 | Submission Open

Keywords: crop protection; plant pathology; plant disease resistance; biotic stress; plant innate immune response

(This special issue belongs to the Section Plant Science)

Molecular Genetics and Immunogenomics of Fishes

edited by

Rodrigo Vidal

submission deadline 30 Mar 2027 | Viewed by 225 | Submission Open

Keywords: fish genomics; immunogenomics; non-coding RNAs; functional genomics; artificial intelligence; host–pathogen interactions; genome evolution; aquaculture; disease resistance; environmental adaptation

(This special issue belongs to the Section Genetics and Genomics)

DNA Repair and DNA Damage Response in Oncology

edited by

Jia Li

submission deadline 30 Mar 2027 | Viewed by 142 | Submission Open

Keywords: DNA repair and DNA damage response pathways; cancer target therapy; DNA replication stress response in genome stability; oxidative stress response and redox regulation; DNA single-strand break repair and signaling

(This special issue belongs to the Section Cancer Biology)

Proteomics and Human Diseases

edited by Lei Fang

submission deadline 31 Mar 2027 | 4 articles | Viewed by 12925 | Submission Open

Keywords: proteomics; clinical proteomics; human diseases; biomarker identification; therapeutic target; molecular mechanism; cancers; metabolic diseases; cardiovascular diseases; neurodegeneration diseases

(This special issue belongs to the Section Medical Biology)

Unraveling the Tumor-Immune Microenvironment Using Transcriptomics

edited by

Leonardo Oliveira Reis

submission deadline 31 Mar 2027 | 3 articles | Viewed by 12370 | Submission Open

Keywords: tumor-immune microenvironment; immune cells; tumor cells; stromal cells; signaling molecules; extracellular matrix (ECM); vascular network

(This special issue belongs to the Section Cancer Biology)

Exploring the Biodiversity, Taxonomy, Ecology and Genomics of Fungi

edited by

Chitrabhanu S. Bhunjun

Chayanard Phukhamsakda

and

Sajeewa Maharachchikumbura

submission deadline 31 Mar 2027 | 4 articles | Viewed by 6938 | Submission Open

Keywords: biodiversity; ecological roles of fungi; fungal communities; genomics; polyphasic approaches; metabolomics

Biodiversity, Conservation, and Application of Crustaceans

edited by

Laorsri Sanoamuang

and Alejandro M. Maeda-Martinez

submission deadline 31 Mar 2027 | 5 articles | Viewed by 6527 | Submission Open

Keywords: application; aquaculture; aquatic ecology; biodiversity and conservation; crustaceans; evolutionary biology; experimental toxicology; genetic diversity; phylogenetic relationships; taxonomy and classification

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Feature Papers in 'Conservation Biology and Biodiversity' (2nd Edition)

edited by

Ettore Randi

submission deadline 31 Mar 2027 | 6 articles | Viewed by 4346 | Submission Open

Keywords: population genomics and diversity; heterozygosity; inbreeding; hybridization; adaptive introgression; natural selection; speciation; bottleneck and population fragmentation; genetic drift; gene flow; extinction risk; evolvability; paleogenomics; phylogeography; conservation units; ecotypes; phylogenetics and systematics; eDNA; non-invasive genetic sampling; environmental monitoring

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Biological Control and Molecular Biology of Bacterial Plant Diseases

edited by Lei Li and Xiaofeng Zhou

submission deadline 31 Mar 2027 | 2 articles | Viewed by 4283 | Submission Open

Keywords: bacterial plant diseases; biological control; plant pathogens; endophytes; genomic, transcriptomic, and proteomic studies of antagonistic or pathogenic bacteria interactions; pathogenic mechanism

(This special issue belongs to the Section Plant Science)

Molecular Insights into Liver Function and Disease

edited by

Isabel Méndez

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1405 | Submission Open

Keywords: liver; metabolism; molecular biology; physiology; inflammation; fibrosis; cirrhosis; hepatocarcinoma

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Displaying special issue 201-250 on page 5 of 8.

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