Periodontal Disease and Periodontal Tissue Regeneration

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 1165

Special Issue Editors


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Guest Editor
Department of Periodontology, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania
Interests: periodontitis etiopathogeny; periodontal medicine; periodontal surgery; periodontal adjunctive treatment
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Odontology-Periodontology and Fixed Prosthodontics Department, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
Interests: periodontal risk factors; periodontal non-surgical therapy; periodontal surgical therapy; periodontal adjunctive treatment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We cordially extend an invitation for you to submit a manuscript for our forthcoming Special Issue on "Periodontal Disease and Periodontal Tissue Regeneration."

Further clarification is needed regarding the onset and evolutionary mechanisms of periodontal disease to ensure appropriate treatment. It is imperative that there is a clear understanding of the underlying causes and factors contributing to the disease. This understanding will facilitate the development of effective treatment plans tailored to individual patient's needs, ultimately improving patient outcomes.

Advancing our understanding of periodontal tissue regeneration is imperative to enhance the quality of life for patients affected by periodontal diseases. Innovations in periodontal tissue engineering hold the promise of revolutionizing dental healthcare, emphasizing the urgency of ongoing research.

All review articles, research articles, and techniques on advanced technologies and methods for periodontal diagnosis and the surgical approach for periodontal tissue regeneration are of interest to this Special Issue. Your contribution to this topic would be greatly appreciated and could potentially provide valuable insights into this area of research. We look forward to receiving your submission and are confident that your work will be of great interest to our readers.

Dr. Irina-Georgeta Sufaru
Dr. Sorina Mihaela Solomon
Guest Editors

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Keywords

  • periodontal diagnosis
  • periodontal immunology
  • periodontal microbiology
  • periodontal tissue regeneration
  • tissue engineering

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Published Papers (1 paper)

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Research

17 pages, 18198 KiB  
Article
Combined Effects of Fibroblast Growth Factor-2 and Carbonate Apatite Granules on Periodontal Healing: An In Vivo and In Vitro Study
by Naoki Miyata, Shinta Mori, Tasuku Murakami, Takahiro Bizenjima, Fumi Seshima, Kentaro Imamura and Atsushi Saito
Biomedicines 2024, 12(8), 1664; https://doi.org/10.3390/biomedicines12081664 - 25 Jul 2024
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Abstract
The aim of this study was to investigate in vivo and in vitro the effectiveness of the use of fibroblast growth factor (FGF)-2 with carbonate apatite (CO3Ap) on periodontal healing. Periodontal defects created in the maxillary first molars in rats were [...] Read more.
The aim of this study was to investigate in vivo and in vitro the effectiveness of the use of fibroblast growth factor (FGF)-2 with carbonate apatite (CO3Ap) on periodontal healing. Periodontal defects created in the maxillary first molars in rats were treated with FGF-2, CO3Ap, FGF-2 + CO3Ap or left unfilled. Healing was evaluated using microcomputed tomography, histological, and immunohistochemical analyses. In vitro experiments were performed to assess cellular behaviors and the expression of osteoblastic differentiation markers in MC3T3-E1 cells. At 4 weeks, the bone volume fraction in the FGF-2 + CO3Ap group was significantly greater than that in the CO3Ap group, but there was no significant difference from the FGF-2 group. The FGF-2 + CO3Ap group demonstrated greater new bone compared with the FGF-2 or CO3Ap group. The FGF-2 + CO3Ap group showed greater levels of osteocalcin-positive cells compared with the CO3Ap group, but there was no significant difference from the FGF-2 group. In vitro, the FGF-2 + CO3Ap group exhibited a greater extent of cell attachment and more elongated cells compared with the CO3Ap group. Compared with the CO3Ap group, the FGF-2 + CO3Ap group showed significantly higher viability/proliferation, but the expressions of Runx2 and Sp7 were reduced. The results indicated that the use of FGF-2 with CO3Ap enhanced healing in the periodontal defects. FGF-2 promoted cell attachment to and proliferation on CO3Ap and regulated osteoblastic differentiation, thereby contributing to novel bone formation. Full article
(This article belongs to the Special Issue Periodontal Disease and Periodontal Tissue Regeneration)
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