Molecular Research of Alzheimer's Disease
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: closed (15 February 2022) | Viewed by 43319
Special Issue Editor
Interests: Alzheimer's disease; neurodegeneration; vascular disease; acute care; critically ill patient
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Alzheimer’s Disease represents a growing health concern, since ageing demographics are actively contributing to a significant increase in its prevalence and incidence. The classical neuropathogenetic model, based on brain amyloid plaque deposition, neurofibrillary tangles and cholinergic system dysfunction is undergoing reconsideration and integration in light of the failure of both amyloid-targeted and cholinesterase-inhibiting therapies. A better understanding of the relationships between the classical pathogenetic pathways and newer hypotheses are urgently required to guide future research and develop effective drugs. The role of risk factors and comorbidities, such as vascular diseases and diabetes mellitus, as well as neurovascular unit dysfunction, are suggesting the existence of newer molecular mechanisms that could represent potential targets for effective Alzheimer’s Disease treatments. The aim of this Special Issue of Biomedicines is to provide an overview of the pathophysiologic role of newer and older molecular mechanisms of Alzheimer’s Disease and to advance new insights for the development of new therapeutic approaches. Moreover, it will focus on newer candidate markers of disease onset and progression. Both original articles and reviews will be considered for publication in this Special Issue.
Dr. Lorenzo Falsetti
Guest Editor
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Related Special Issue
- Molecular Research of Alzheimer's Disease 2.0 in Biomedicines (2 articles)