Genomic and Epigenomic Alterations in Gastrointestinal (GI) Cancers
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 15512
Special Issue Editors
Interests: epigenetic and genetic alterations in gastrointestinal (GI) cancers; biomarkers for early detection and prognostication of GI cancer; role of gut microbiome in GI cancers; non-alcoholic steatohepatitis-associated liver cancer
Interests: tumor metabolism and epigenetic interplay in gastrointestinal (GI) cancers; KRAS-mutant colorectal cancer; therapeutic targets in GI cancers
Special Issue Information
Dear Colleagues,
Gastrointestinal cancer (GI) (stomach, colon, liver) constitutes about 50% of all malignancies globally. Moreover, the incidence of GI cancers has been rising over the past 5 to 10 years, thus posing a serious threat to human health and representing a healthcare burden. Over the past decade, multiple international genetic, transcriptomic and epigenetic sequencing projects have established that aberrant genetic and epigenetic regulation plays key roles in the pathogenesis of GI cancers. More recently, the emergence of epitranscriptomics—the epigenetic modification of RNA—has provided an additional dimension for gene regulation in GI cancers. Genetic mutations, as well as epigenetic and epitranscriptomic alterations, are all fundamental to processes involved in the multifaceted aspects of GI cancer, including cancer cell proliferation, metastatic potential, adaptation to tumor microenvironment, modulation of antitumor immune response, and interaction with the gut microbiome. Understanding of genetic and epigenetic alterations in GI cancers will be critical to unveil novel therapeutic targets and molecular biomarkers to improve disease diagnosis and treatment.
The aim of this Special Issue is to gather reviews and research papers focusing on the role of genetic, epigenetic and epitranscriptomic alterations in the regulation of GI cancers, highlighting new insights into their roles in tumor initiation and progression, and how novel these discoveries can be translated to the clinic to improve patient care in GI cancers.
Prof. Dr. Jun Yu
Dr. Chi Chun Wong
Guest Editors
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Keywords
- epigenetics
- epitranscriptomics
- genetics
- gastrointestinal cancers
- tumorigenesis
- tumor microenvironment
- tumor microbiome
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