Recent Advances in Endocrine Disease and Atherosclerosis

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 476

Special Issue Editor


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Guest Editor
1. Department of Medicine, University of Valencia and Endocrinology, 46010 Valencia, Spain
2. Nutrition Department, Hospital Clinico Universitario of Valencia, 46010 Valencia, Spain
3. INCLIVA Biomedical Research Institute, 46010 Valencia, Spain
4. CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain
Interests: diabetes; dyslipidemia; insulin resistance; atherosclerosis; cardiovascular disease; inflammation
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Special Issue Information

Dear Colleagues,

Atherosclerosis is one of the leading causes of death in the world. Many factors have been associated with the development of atherosclerosis and cardiovascular disease. Different endocrine disorders, such as diabetes, dyslipidemia, obesity, acromegaly, Cushing’s syndrome, and hypothyroidism, have been associated with accelerated atherosclerosis and coronary artery disease.

This Special Issue of Biomedicines focuses on recent advances in the etiology, pathogenesis, diagnosis, and treatment of endocrine disorders related to atherosclerosis and cardiovascular disease development. Detailed knowledge on this topic is needed to prevent the development of cardiovascular disease.

Dr. Sergio Martínez-Hervás
Guest Editor

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Keywords

  • diabetes
  • dyslipidemia
  • obesity
  • insulin resistance
  • subclinical atherosclerosis
  • atherosclerosis
  • cardiovascular disease

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Published Papers (1 paper)

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Research

12 pages, 272 KB  
Article
Increased CX3CL1/CX3CR1 Axis Is Related to Atherosclerosis in Subjects with Familial Combined Hyperlipidaemia, Which Is Modulated by Insulin Resistance but Not by Sex
by Elena Jiménez-Martí, Clara Espinosa-Bellido, Blanca Alabadi, Gema Hurtado-Genovés, Antonio Enrique-Medina, Susana Martín-Vañó, Víctor Casas, Eduardo A. Cortés Nadal, José T. Real, Herminia González-Navarro and Sergio Martínez-Hervás
Biomedicines 2025, 13(10), 2378; https://doi.org/10.3390/biomedicines13102378 (registering DOI) - 28 Sep 2025
Abstract
Background: A major factor in the development of atherosclerosis is the presence of a chronic inflammatory state. The CX3CL1/CX3CR1 axis has been implicated in the development of atherosclerosis and cardiovascular disease, but until now, scarce data are available [...] Read more.
Background: A major factor in the development of atherosclerosis is the presence of a chronic inflammatory state. The CX3CL1/CX3CR1 axis has been implicated in the development of atherosclerosis and cardiovascular disease, but until now, scarce data are available regarding the influence of the CX3CL1/CX3CR1 axis in familial combined hyperlipidaemia (FCH). Since FCH is associated with a high risk of cardiovascular disease, the objective of the present study was to assess the presence of alterations in the CX3CL1/CX3CR1 axis in patients with FCH and to evaluate the influence of insulin resistance (IR) and sex. Methods: A cohort of 47 subjects with FCH and 38 control subjects was included. We measured the lipid profile, glucose, and insulin levels in plasma, circulating blood CX3CL1 levels, and CX3CR1 mRNA expression. Carotid IMT and the presence of atheroma plaques were also evaluated. Results: FCH subjects showed significantly higher activation of the CX3CL1/CX3CR1 axis than controls. In addition, FCH individuals with IR showed the worst profile of inflammation status, higher carotid IMT, and a higher prevalence of atherosclerotic plaque compared to controls and FCH patients without IR. However, sex did not influence the CX3CL1/CX3CR1 axis. Conclusions: FCH patients showed an increased CX3CL1/CX3CR1 axis, which was positively correlated with IR, but not with sex. These data could partially explain the increased risk of cardiovascular events in primary dyslipidemic patients. Full article
(This article belongs to the Special Issue Recent Advances in Endocrine Disease and Atherosclerosis)
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