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Emergent Lifestyle Modifications and Therapeutic Strategies in Cardiometabolic Control

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 4810

Special Issue Editors


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Guest Editor
1. Department of Biochemistry and Molecular Biology, University of Valencia, 46010 Valencia, Spain
2. Health Research Institute Clinic Hospital of Valencia – INCLIVA, Blasco Ibáñez, 15, 46010 Valencia, Spain
Interests: metabolic control; inflammation; diabetes; atherosclerosis; fatty liver
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Medicine, University of Valencia and Endocrinology, 46010 Valencia, Spain
2. Nutrition Department, Hospital Clinico Universitario of Valencia, 46010 Valencia, Spain
3. INCLIVA Biomedical Research Institute, 46010 Valencia, Spain
4. CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain
Interests: diabetes; dyslipidemia; insulin resistance; atherosclerosis; cardiovascular disease; inflammation
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Biochemistry and Molecular Biology, University of Valencia, 46010 Valencia, Spain
2. Health Research Institute Clinic Hospital of Valencia – INCLIVA, Blasco Ibáñez, 15, 46010 Valencia, Spain
Interests: metabolic biochemistry; hepatic homeostasis; diabetes; atherosclerosis; drug development; gene expression regulation

Special Issue Information

Dear Colleagues,

Metabolic control has become a major challenge worldwide. The lack of metabolic control, mostly caused by dysregulated plasmatic lipid levels and uncontrolled glucose metabolism, has provoked diabetes in up to 422 million people globally. Currently, the existence of intensive therapies for management of metabolic derangement has contributed to reducing these risks. However, the morbimortality attributed to the pathologic complications associated with poor metabolic control, ranging from cardiovascular disease to non-alcoholic steatohepatitis and hepatocarcinoma, has achieved unacceptable prevalence. In recent decades, dietary interventions as well as the development of drugs targeted at different metabolic genes have been explored. Both strategies, which have been studied in animal models and clinical trials, have been shown to be able to modify intertissular and intratissular molecular flux. These changes affect many biochemical and inflammatory factors, which have been partially deciphered but need further understanding in order to efficiently reduce the morbimortality associated with the loss of metabolic homeostasis.

This Special Issue of Nutrients, entitled “Emergent Lifestyle Modifications and Therapeutic Strategies in Cardiometabolic Control”, welcomes the submission of manuscripts describing original research, reviews of the scientific literature, systematic reviews, and meta-analyses. These studies may describe investigations that deepen our understanding of the mechanistic aspects of metabolic derangement discoveries as well as of current and emergent therapies.

Dr. Herminia González-Navarro
Dr. Sergio Martínez-Hervás
Dr. Elena Jiménez-Martí
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lifestyle changes
  • cardiometabolic therapies
  • metabolic control
  • fatty liver
  • cardiovascular disease
  • insulin resistance

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Published Papers (1 paper)

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Review

25 pages, 705 KiB  
Review
Novel Therapies for Cardiometabolic Disease: Recent Findings in Studies with Hormone Peptide-Derived G Protein Coupled Receptor Agonists
by Elena Jiménez-Martí, Gema Hurtado-Genovés, María Aguilar-Ballester, Sergio Martínez-Hervás and Herminia González-Navarro
Nutrients 2022, 14(18), 3775; https://doi.org/10.3390/nu14183775 - 13 Sep 2022
Cited by 3 | Viewed by 4441
Abstract
The increasing prevalence of obesity and type 2 diabetes (T2DM) is provoking an important socioeconomic burden mainly in the form of cardiovascular disease (CVD). One successful strategy is the so-called metabolic surgery whose beneficial effects are beyond dietary restrictions and weight loss. One [...] Read more.
The increasing prevalence of obesity and type 2 diabetes (T2DM) is provoking an important socioeconomic burden mainly in the form of cardiovascular disease (CVD). One successful strategy is the so-called metabolic surgery whose beneficial effects are beyond dietary restrictions and weight loss. One key underlying mechanism behind this surgery is the cooperative improved action of the preproglucagon-derived hormones, glucagon, glucagon-like peptide-1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP) which exert their functions through G protein-coupled receptors (GPCR). Great success has been reached with therapies based on the GLP-1 receptor monoagonism; therefore, a logical and rational approach is the use of the dual and triagonism of GCPC to achieve complete metabolic homeostasis. The present review describes novel findings regarding the complex biology of the preproglucagon-derived hormones, their signaling, and the drug development of their analogues, especially those acting as dual and triagonists. Moreover, the main investigations into animal models and ongoing clinical trials using these unimolecular dual and triagonists are included which have demonstrated their safety, efficacy, and beneficial effects on the CV system. These therapeutic strategies could greatly impact the treatment of CVD with unprecedented benefits which will be revealed in the next years. Full article
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