Perinatal-Related Pathology Volume II

Dear Colleagues,

An increasing amount of data indicate that the majority of cases of the so-called great obstetrics syndrome are caused by dysfunction of the placenta, which is caused by its impaired development or too-early functional impairment. Today, a holistic approach to maternal-fetal medicine allows us to explore the causes and primary pathogenesis of subsequent clinical syndromes.

The proposed Special Issue aims to focus on the presentation of modern approaches to pathogenesis and diagnostic methods that take advantage of the primary trophoblast impairment and allow the detection of potential threats in advance.

Pregnant women with clinical symptoms of placental insufficiency are still doomed to iatrogenic premature termination of pregnancy, and the severity of the pathology is correlated with perinatal outcomes. Therefore, it is worth looking for genetic, biochemical, and biophysical methods that can be used to monitor the course of the disease, and in some situations prevent serious complications.

In recent years, attention has been paid to the role of the microbiome in the pathogenesis of many pathological conditions. There are also studies on the microbiome in the context of maternal-fetal medicine. A relationship is sought between the type of bacteria inhabiting the gastrointestinal tract of women and the occurrence of obesity, gestational diabetes, or premature birth, as well as hypoxia and intrauterine infection. Other metabolomes, such as maternal and newborn urine, amniotic fluid, human breast milk, and meconium of the newborn, are also tested. In research on the microbiome in the newborn, the relationship with civilization diseases, infections, and eating disorders is sought. Is it possible to get closer to personalized medicine by using metabolomics?

Prof. Dr. Agnieszka Kordek
Dr. Andrzej Torbé
Guest Editors

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• trophoblast markers
• preeclampsia
• maternal and perinatal consequences of placental insufficiency
• fetal growth restriction
• prediction and diagnostics
• microbiome
• metabolomics
• neonatal sepsis
• newborn of diabetic mother
• congenital defects and prenatal diagnosis