Role of Insulin Metabolism in Insulin Action and Metabolic Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".
Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 14083
Special Issue Editors
2. Diabetes Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701-2979, USA
Interests: diabetes; hypertension; insulin resistance; metabolism; metabolic diseases; physiology
Special Issues, Collections and Topics in MDPI journals
Interests: insulin resistance; hepatology; diabetes; hypertension; metabolic syndrome; glucose metabolism; fatty liver; metabolism; nutrition
Special Issues, Collections and Topics in MDPI journals
2. AUB Diabetes, American University of Beirut, Beirut, Lebanon
Interests: liver-specific ablation; hepatic insulin resistance; glucose intolerance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic diseases are reaching an epidemic worldwide. In addition to insulin resistance, altered insulin secretion and clearance contribute to the worsening of glucose tolerance. Upon its secretion from pancreatic beta cells, insulin is metabolized mostly by the liver (the first target organ), and subsequently, by peripheral tissues, in particular skeletal muscle. Thus, peripheral insulin concentrations are the result of a balance between insulin secretion and clearance. The mechanisms underlying insulin secretion have been widely explored. In contrast, mechanisms underlying insulin clearance remain poorly understood. This special issue focuses on presenting a comprehensive view on the regulation of insulin homeostasis with an overarching goal to highlight the current knowledge on the mechanisms as well as the physiologic impact of altered insulin clearance (and secretion) on metabolic processes.
We invite investigators to contribute either original research or review articles focusing on the variety of molecular mechanisms of altered insulin secretion and clearance, and their role in the pathogenesis of cardiometabolic diseases that include, but are not limited to, type 2 diabetes, non-alcoholic fatty liver disease (NAFLD/NASH), atherosclerosis, hypertension in animal models and in subjects with different degrees of glucose intolerance. Articles should also discuss how these mechanisms cause or contribute to the progression to type 2 diabetes and associated metabolic disease, and how they are modulated by race and environmental factors.
You may choose our Joint Special Issue in International Journal of Molecular Sciences.
Prof. Dr. Sonia Michael Najjar
Prof. Dr. Amalia Gastaldelli
Dr. Hilda E. Ghadieh
Guest Editors
Manuscript Submission Information
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Keywords
- Insulin secretion
- Insulin clearance
- Insulin endocytosis and degradation
- Insulin signaling and metabolism
- Mechanisms of altered insulin clearance
- Hepatic vs. peripheral insulin extraction
- Insulin uptake in endothelial cells and extrahepatic extraction
- Racial disparity in insulin clearance
- Environmental factors and insulin clearance
- Insulin metabolism and cardiometabolic disease
- Drugs targeting insulin clearance
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