Homocysteine and H2S in Health and Disease, 2nd Edition
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 378
Special Issue Editors
Interests: cell physiology; ion channels; Ca2+-activated K+ channels; cellular excitability; gasotransmitters
Special Issues, Collections and Topics in MDPI journals
Interests: neurophysiology; development; homocysteine; ion channels; hydrogen sulfide; synaptic transmission; migraine; pain
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Following a very successful first publication of the Special Issue “Homocysteine and H2S in Health and Disease”, we are now pleased to announce the launch of a second edition that will focus on new and interesting discoveries and their medical applications in the field.
Homocysteine (Hcy) and gaseous hydrogen sulphide (H2S) are two physiologically active molecules produced in the metabolic cycle of methionine that must be precisely regulated. An increased level of homocysteine in the plasm, called hyperhomocysteinemia (HHcy), may be the result of several hereditary and acquired factors, including a deficiency or genetic polymorphism of enzymes associated with homocysteine metabolism; renal failure; a deficit of vitamins B6, B9 and B12; or the administration of medication such as antiepileptic drugs or L-DOPA. HHcy induces oxidative stress and inflammation in many tissues and is associated with numerous pathologies like cardiovascular diseases, neurodegeneration, osteoporosis, migraine, epilepsy, developmental disorders, etc.
Hcy levels are regulated by remethylation and transsulfuration pathways. The key enzymes in transsulfuration pathways are cystathionine β-synthase and cystathionine γ-lyase, which are involved in the biosynthesis of H2S. In addition, H2S can be synthesized by the activity of cysteine aminotransferase and 3-mercaptopyruvate sulfurtransferase.
In this Special Issue, we will focus on the links between the metabolism of homocysteine and H2S, the imbalance of homocysteine and H2S in different pathologies, the mechanisms behind the protective effects of H2S in homocysteine toxicity, and approaches to maintaining the endogenous balance between these two molecules to prevent this condition in patients.
Prof. Dr. Anton Hermann
Prof. Dr. Guzel F. Sitdikova
Guest Editors
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Keywords
- homocysteine (Hcy)
- hydrogen sulfide (H2S)
- oxidative stress
- inflammation
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Related Special Issue
- Homocysteine and H2S in Health and Disease in Biomolecules (6 articles)
