Biomolecular Approaches and Drugs for Neurodegeneration—2nd Edition
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 56
Special Issue Editors
Interests: pharmaceutical chemistry; neurodrugs; protein interactions; spectroscopy; computational chemistry; phytochemistry
Special Issues, Collections and Topics in MDPI journals
Interests: spectroscopy; computational chemistry; biomolecular binding; bioactive compounds; drug discovery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuropathologies are very common and disabling conditions affecting the ever-growing elderly population around the world, especially in Western countries. There is an urgent need to develop effective therapies to prevent or treat neuropathologies. Protein/peptide aggregation is of fundamental importance in therapeutics because this type of event is related to pathologies of enormous social relevance, including neurodegeneration. Interestingly, G-quadruplex (G4) DNA and RNA structures are also related to several neuropathologies, and ligands that can destabilize or modulate the aggregation of these nucleic acid secondary structures have therefore been proposed as having the potential to work as neurodrugs. In this Special Issue, we will focus on current experimental and theoretical approaches to neurodrug design and development, with a particular focus on the mechanisms underlying drug interference with protein and peptide aggregation pathways; however, contributions on G4 nucleic acid–drug interactions, G4 targets in neurodegenerative diseases, and nucleopeptide chemistry are also welcome, as they could improve our overall knowledge of the aggregation-based biochemistry at the interface between neurodrug design and therapy. Other themes of interest include applications of computational chemistry and machine learning to chemistry and biology in the context of neuropathology therapy. For this Special Issue, we welcome submissions of original articles and reviews that discuss research and ideas on the theme of neurodegeneration-related molecular strategies.
Dr. Caterina Vicidomini
Dr. Giovanni N. Roviello
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- proteins
- peptides
- amyloid
- Alzheimer disease
- Parkinson’s disease
- neurodrugs
- G-quadruplex nucleic acids
- biotechnology
- biomolecular targets
- peptide aggregation
- natural products
- synthetic drugs
- anti-amyloid therapeutics
- machine learning
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
Related Special Issue
- Biomolecular Approaches and Drugs for Neurodegeneration in Biomolecules (11 articles)
