Biomolecular Approaches and Drugs for Neurodegeneration—2nd Edition
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 264
Special Issue Editors
Interests: pharmaceutical chemistry; neurodrugs; protein interactions; spectroscopy; computational chemistry; phytochemistry
Special Issues, Collections and Topics in MDPI journals
Interests: spectroscopy; computational chemistry; biomolecular binding; bioactive compounds; drug discovery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuropathologies are very common and disabling conditions affecting the ever-growing elderly population around the world, especially in Western countries. There is an urgent need to develop effective therapies to prevent or treat neuropathologies. Protein/peptide aggregation is of fundamental importance in therapeutics because this type of event is related to pathologies of enormous social relevance, including neurodegeneration. Interestingly, G-quadruplex (G4) DNA and RNA structures are also related to several neuropathologies, and ligands that can destabilize or modulate the aggregation of these nucleic acid secondary structures have therefore been proposed as having the potential to work as neurodrugs. In this Special Issue, we will focus on current experimental and theoretical approaches to neurodrug design and development, with a particular focus on the mechanisms underlying drug interference with protein and peptide aggregation pathways; however, contributions on G4 nucleic acid–drug interactions, G4 targets in neurodegenerative diseases, and nucleopeptide chemistry are also welcome, as they could improve our overall knowledge of the aggregation-based biochemistry at the interface between neurodrug design and therapy. Other themes of interest include applications of computational chemistry and machine learning to chemistry and biology in the context of neuropathology therapy. For this Special Issue, we welcome submissions of original articles and reviews that discuss research and ideas on the theme of neurodegeneration-related molecular strategies.
Dr. Caterina Vicidomini
Dr. Giovanni N. Roviello
Guest Editors
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Keywords
- proteins
- peptides
- amyloid
- Alzheimer disease
- Parkinson’s disease
- neurodrugs
- G-quadruplex nucleic acids
- biotechnology
- biomolecular targets
- peptide aggregation
- natural products
- synthetic drugs
- anti-amyloid therapeutics
- machine learning
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Related Special Issue
- Biomolecular Approaches and Drugs for Neurodegeneration in Biomolecules (11 articles)
