Endogenous versus Exogenous DNA Adducts: Their Role in Carcinogenesis, Inflammation, Epidemiology, and Risk Assessment
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Nucleic Acids".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2442
Special Issue Editor
Interests: DNA damage and DNA adducts; genotoxicity; mutagenicity; myeloperoxidase- and neutrophil-mediated metabolism; hydrogen peroxide; hypochlorous acid; oxidative degradation of bilirubin; biomarkers; environmental pollutants
Special Issue Information
Dear Colleagues,
DNA adducts are a form of DNA damage caused by the covalent attachment of a chemical moiety to DNA. If left unrepaired, they can lead to mutations, contributing to the occurrence of cancers. Thus, the formation of DNA adducts is generally accepted as the initiating molecular event in carcinogenesis. The structures of DNA adducts can indicate the chemicals causing the formation of adducts, and the levels of adducts may be associated with the cancer risks. Thus, DNA adducts are biomarkers of both exposure and effects, and can be used in biomonitoring and cancer risk assessment.
Most studies have focused on DNA adducts caused by exogenous chemicals; however, DNA adducts can also be formed endogenously through interactions with reactive molecules (or radicals) generated in the endogenously physiological processes, such as formaldehyde, 4-hydroxy-2-nonenal, and reactive oxygen species (ROS). 8-Oxo-deoxyguanosine, a common product of DNA oxidation by ROS, is an endogenous DNA adduct.
Although they are usually associated with carcinogenesis, DNA adducts also play an important role in other biological processes, such as senescence and inflammation. Inflammation has been known to be a critical contributor to tumor promotion and progression. In the meantime, inflammation can also lead to the production of ROS, thus indirectly inducing the formation of DNA adducts. Therefore, the formation of DNA adducts can trigger diverse biological processes, beyond mutations and carcinogenesis.
Clearly, the formation of DNA adducts is an extremely important biological event, and the related studies will greatly contribute to our understanding of critical biological processes and underlying molecular mechanisms. Meanwhile, as key biomarkers of exposure and effects, DNA adducts can have many applications in the epidemiology and risk assessment of chemicals. In the Special Issue, authors are invited to submit manuscripts to delineate the roles of DNA adducts in various biological processes, in particular in carcinogenesis and inflammation, and to investigate the applications of DNA adducts in epidemiology and risk assessment. In an era of -omics, DNA adductomics is certainly covered in this Special Issue. However, our major focus is on biochemistry and molecular biology (in vitro and in vivo studies); we will not cover clinical and analytical chemical studies. Review articles will also be considered.
Dr. Xinyu Zhang
Guest Editor
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Keywords
- DNA adducts
- DNA adductomics
- mutagenesis
- carcinogenesis
- inflammation
- molecular mechanisms
- biomarkers
- biomonitoring
- risk assessment
- environmental pollutants
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