Chronic Heart Failure: From Molecular Mechanisms to Therapies Strategies
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 462
Special Issue Editors
2. Bio-Heart Cardiovascular Diseases Research Group, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain
3. Community Heart Failure Program, Cardiology Department, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain
4. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto Salud Carlos III, 28029 Madrid, Spain
5. Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain
Interests: chronic heart failure; eHealth; telemedicine; transitional care; chronic care model
Special Issues, Collections and Topics in MDPI journals
2. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto Salud Carlos III, 28029 Madrid, Spain
Interests: heart failure; iron metabolism; biomarkers; molecular pathways
Special Issue Information
Dear Colleagues,
Chronic heart failure (CHF) is a devastating syndrome with a very negative impact on mortality, morbidity, and the health-related quality of life of patients with this diagnosis. CHF also represents a challenge to healthcare systems due to its growing prevalence and to the rising medical resource use and expenditure associated with this syndrome.
The current understanding of its pathophysiology is based on the “neurohormonal hypothesis”, which states that CHF progression is promoted by the long-term maladaptive and deleterious effects of sustained neurohormonal activation in the heart and in the rest of the cardiovascular system. The inhibition of these neurohormonal systems has demonstrated a consistent reduction in morbidity and mortality in patients with systolic HF and is the basis of modern pharmacological treatment. However, these effective therapies have failed to promote a complete remission of symptoms and restore life expectancy in many patients.
This Special Issue will provide novel findings and innovations in the field of CHF pathophysiology, potential new biomarkers, and therapies. This understanding is essential for the development of early diagnostic tools, improved risk management strategies, and innovative prevention methods. A multidisciplinary and integrated management approach is essential to achieve such an ambitious challenge.
Dr. Josep Comín-Colet
Dr. Marta Tajes
Guest Editors
Manuscript Submission Information
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Keywords
- chronic heart failure
- pathophysiology
- comorbidities
- new therapies
- molecular pathways
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