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Bisphenol A: An Environmental Factor with an Emerging Role in...
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Bisphenol A: An Environmental Factor with an Emerging Role in the Pathophysiology of Renal and Cardiovascular Diseases

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: closed (13 August 2021) | Viewed by 15493

Special Issue Editors

Prof. Ricardo José Bosch

E-Mail Website
Guest Editor
Department of Biological Systems/ Unit of Physiology, Alcalá School of Medicine, Autovía de Aragón km 33,600, 28871 Alcalá de Henares, Spain
Interests: bisphenol A; parathyroid hormone related protein (PTHrP) experimental nephrology; diabetic nephropathy; acute kidney injury (AKI)
Special Issues, Collections and Topics in MDPI journals
Dr. Marta Saura

E-Mail Website
Guest Editor
Department of Biology Systems, Physiology Unit, University of Alcalá, 28871 Alcalá de Henares, Spain
Interests: nitric oxide; bisphenol A; integrin linked kinase; vascular disease; cardiac remodeling; extracellular matrix

Special Issue Information

Dear Colleagues,

In recent years, exposure to certain chemical substances has become a part of everyday life. Such is the case with bisphenol A (BPA), a chemical—xenoestrogen—used in the production of food containers which is present in the urine of almost the entire population. As a known endocrine disruptor, BPA has been implicated in several endocrine and metabolic abnormalities, including hepatic and thyroid disorders, obesity, and insulin resistance. From a renovascular perspective, numerous studies have found a significant correlation among BPA exposure with podocytopathy, albuminuria, hypertension, and cardiovascular abnormalities. Results obtained experimentally are supported by epidemiological studies conducted in New York, Shanghai, and Seoul, which describe an association between human exposure to BPA and an increased in proteinuria and hypertension. Several studies have demonstrated that these associations are independent of sex, diabetes, smoking status, hypertension, or chronic kidney disease. In this way, high urinary BPA excretion was associated with arterial hypertension independently of other classic risk factors.

This Special Issue of Biomolecules aims to provide an updated view of BPA as an environmental factor implicated in the pathophysiology of renal and cardiovascular diseases. For this purpose, contributions have been selected based on the expertise of recognized scientists in the field. Discussions in this volume include described BPA features as a compound which is capable of promoting both experimental and human podocytopathy, including albuminuria. Moreover, reported data show that animals treated with BPA develop hypertension, endothelial dysfunction, and in cardiac endothelial cells can also promote a novel type of programmed cell necrosis—necroptosis—that could lead to heart dysfunction. Thus, discussions on novel cardiovascular BPA effects which could affect renal disease are encouraged. In summary, we hope the different topics of BPA in renal and cardiovascular diseases presented in this volume will be found attractive for both basic and clinical researchers in the field.

Prof. Ricardo José Bosch
Dr. Marta Saura
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bisphenol A (BPA)
  • Podocytes
  • Albuminuria
  • Hypertension
  • Cardiac abnormalities
  • Endothelial disfunction
  • Nitric oxide synthase
  • Angiotensin II and calcium-calmodulin kinase II (CaMKII)
  • Necroptosis

Published Papers (6 papers)

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Editorial

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4 pages, 217 KiB  
Editorial
New Evidence of Renal and Cardiovascular Alterations Promoted by Bisphenol A
by Rafael Moreno-Gómez-Toledano, María I. Arenas, Esperanza Vélez-Vélez, Marta Saura and Ricardo J. Bosch
Biomolecules 2021, 11(11), 1649; https://doi.org/10.3390/biom11111649 - 8 Nov 2021
Cited by 3 | Viewed by 1349
Abstract
Bisphenol A (BPA) is a phenolic compound that is widely used to synthesize plastics as a monomer or additive [...] Full article
(This article belongs to the Special Issue Bisphenol A: An Environmental Factor with an Emerging Role in the Pathophysiology of Renal and Cardiovascular Diseases)

Research

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16 pages, 3205 KiB  
Article
Bisphenol A Induces Accelerated Cell Aging in Murine Endothelium
by Rafael Moreno-Gómez-Toledano, Sandra Sánchez-Esteban, Alberto Cook, Marta Mínguez-Moratinos, Rafael Ramírez-Carracedo, Paula Reventún, María Delgado-Marín, Ricardo J. Bosch and Marta Saura
Biomolecules 2021, 11(10), 1429; https://doi.org/10.3390/biom11101429 - 29 Sep 2021
Cited by 15 | Viewed by 2865
Abstract
Bisphenol A (BPA) is a widespread endocrine disruptor affecting many organs and systems. Previous work in our laboratory demonstrated that BPA could induce death due to necroptosis in murine aortic endothelial cells (MAECs). This work aims to evaluate the possible involvement of BPA-induced [...] Read more.
Bisphenol A (BPA) is a widespread endocrine disruptor affecting many organs and systems. Previous work in our laboratory demonstrated that BPA could induce death due to necroptosis in murine aortic endothelial cells (MAECs). This work aims to evaluate the possible involvement of BPA-induced senescence mechanisms in endothelial cells. The β-Gal assays showed interesting differences in cell senescence at relatively low doses (100 nM and 5 µM). Western blots confirmed that proteins involved in senescence mechanisms, p16 and p21, were overexpressed in the presence of BPA. In addition, the UPR (unfolding protein response) system, which is part of the senescent phenotype, was also explored by Western blot and qPCR, confirming the involvement of the PERK-ATF4-CHOP pathway (related to pathological processes). The endothelium of mice treated with BPA showed an evident increase in the expression of the proteins p16, p21, and CHOP, confirming the results observed in cells. Our results demonstrate that oxidative stress induced by BPA leads to UPR activation and senescence since pretreatment with N-acetylcysteine (NAC) in BPA-treated cells reduced the percentage of senescent cells prevented the overexpression of proteins related to BPA-induced senescence and reduced the activation of the UPR system. The results suggest that BPA participates actively in accelerated cell aging mechanisms, affecting the vascular endothelium and promoting cardiovascular diseases. Full article
(This article belongs to the Special Issue Bisphenol A: An Environmental Factor with an Emerging Role in the Pathophysiology of Renal and Cardiovascular Diseases)
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15 pages, 3594 KiB  
Article
Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03–16 Study
by Rafael Moreno-Gómez-Toledano, María I. Arenas, Esperanza Vélez-Vélez, Elisabeth Coll, Borja Quiroga, Jordi Bover and Ricardo J. Bosch
Biomolecules 2021, 11(7), 1046; https://doi.org/10.3390/biom11071046 - 16 Jul 2021
Cited by 24 | Viewed by 3644
Abstract
Bisphenol A (BPA) is a compound that is especially widespread in most commonly used objects due to its multiple uses in the plastic industry. However, several data support the need to restrict its use. In recent years, new implications of BPA on the [...] Read more.
Bisphenol A (BPA) is a compound that is especially widespread in most commonly used objects due to its multiple uses in the plastic industry. However, several data support the need to restrict its use. In recent years, new implications of BPA on the renal system have been discovered, which denotes the need to expand studies in patients. To this end, a systematic review and a meta-analysis was performed to explore existing literature that examines the BPA-kidney disease paradigm and to determine what and how future studies will need to be carried out. Our systematic review revealed that only few relevant publications have focused on the problem. However, the subsequent meta-analysis revealed that high blood concentrations of BPA could be a factor in developing kidney disease, at least in people with previous pathologies such as diabetes or hypertension. Furthermore, BPA could also represent a risk factor in healthy people whose urinary excretion is higher. Finally, the data analyzed from the NHANES 03-16 cohort provided new evidence on the possible involvement of BPA in kidney disease. Therefore, our results underline the need to carry out a thorough and methodologically homogeneous study, delving into the relationship between urinary and blood BPA, glomerular filtration rate, and urine albumin-to-creatinine ratio, preferably in population groups at risk, and subsequently in the general population, to solve this relevant conundrum with critical potential implications in Public Health. Full article
(This article belongs to the Special Issue Bisphenol A: An Environmental Factor with an Emerging Role in the Pathophysiology of Renal and Cardiovascular Diseases)
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14 pages, 2085 KiB  
Article
Effectiveness of N-Acetylcysteine in the Treatment of Renal Deterioration Caused by Long-Term Exposure to Bisphenol A
by Anongporn Kobroob, Wachirasek Peerapanyasut, Sirinart Kumfu, Nipon Chattipakorn and Orawan Wongmekiat
Biomolecules 2021, 11(5), 655; https://doi.org/10.3390/biom11050655 - 29 Apr 2021
Cited by 16 | Viewed by 2313 | Correction
Abstract
Human health hazards caused by bisphenol A (BPA), a precursor for epoxy resins and polycarbonate-based plastics, are well documented and are closely associated with mitochondrial impairment and oxidative imbalance. This study aimed to assess the therapeutic efficacy of N-acetylcysteine (NAC) on renal deterioration [...] Read more.
Human health hazards caused by bisphenol A (BPA), a precursor for epoxy resins and polycarbonate-based plastics, are well documented and are closely associated with mitochondrial impairment and oxidative imbalance. This study aimed to assess the therapeutic efficacy of N-acetylcysteine (NAC) on renal deterioration caused by long-term BPA exposure and examine the signaling transduction pathway involved. Male Wistar rats were given vehicle or BPA orally for 12 weeks then the BPA-treated group was subdivided to receive vehicle or NAC concurrently with BPA for a further 4 weeks, while the vehicle-treated normal control group continued to receive vehicle through to the end of experiment. Proteinuria, azotemia, glomerular filtration reduction and histopathological abnormalities caused by chronic BPA exposure were significantly reduced following NAC therapy. NAC also diminished nitric oxide and lipid peroxidation but enhanced renal glutathione levels, and counteracted BPA-induced mitochondrial swelling, increased mitochondrial reactive oxygen species production, and the loss of mitochondrial membrane potential. The benefit of NAC was related to the modulation of signaling proteins in the AMPK-SIRT3-SOD2 axis. The present study shows the potential of NAC to restore mitochondrial integrity and oxidative balance after long-term BPA exposure, and suggests that NAC therapy is an effective approach to tackle renal deterioration in this condition. Full article
(This article belongs to the Special Issue Bisphenol A: An Environmental Factor with an Emerging Role in the Pathophysiology of Renal and Cardiovascular Diseases)
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Other

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5 pages, 551 KiB  
Commentary
Strategies to Protect Dialysis Patients against Bisphenol A
by Borja Quiroga
Biomolecules 2021, 11(9), 1375; https://doi.org/10.3390/biom11091375 - 17 Sep 2021
Cited by 4 | Viewed by 1762
Abstract
Bisphenol A (BPA), also known as 2,2,-bis(4-hydroxyphenyl) propane, is a common component of plastics worldwide. However, it has been shown to act as an endocrine disruptor with some hormonal functions. Furthermore, high levels of BPA have been related to the development of cardiovascular [...] Read more.
Bisphenol A (BPA), also known as 2,2,-bis(4-hydroxyphenyl) propane, is a common component of plastics worldwide. However, it has been shown to act as an endocrine disruptor with some hormonal functions. Furthermore, high levels of BPA have been related to the development of cardiovascular events and the activation of carcinogenesis pathways. Patients with chronic kidney disease (CKD) have higher serum concentrations of BPA due to their impaired renal function. This situation is aggravated in CKD patients requiring dialysis, because the BPA content of dialysis devices (such as, for example, the filters) is added to the lack of excretion. In addition to the development of BPA-free dialysis filters, some techniques can contribute to the reduction of BPA levels in these patients. The aim of this review is to illustrate the impact of BPA on dialysis patients and suggest some strategies to reduce its inherent risks. Full article
(This article belongs to the Special Issue Bisphenol A: An Environmental Factor with an Emerging Role in the Pathophysiology of Renal and Cardiovascular Diseases)
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3 pages, 12406 KiB  
Comment
Comment on Kobroob et al. Effectiveness of N-Acetylcysteine in the Treatment of Renal Deterioration Caused by Long-Term Exposure to Bisphenol A. Biomolecules 2021, 11, 655
by Liang-Jun Yan
Biomolecules 2021, 11(6), 888; https://doi.org/10.3390/biom11060888 - 15 Jun 2021
Viewed by 2381
Abstract
Bisphenol A (BPA: 2,2-bis-(4-hydroxyphenyl)-propane) is an industrial chemical that is widely used in the production of epoxy resins and polycarbonate for food containers and plastic bottles [...] Full article
(This article belongs to the Special Issue Bisphenol A: An Environmental Factor with an Emerging Role in the Pathophysiology of Renal and Cardiovascular Diseases)
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