Brain-Derived Neurotrophic Factor in Health and Diseases
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (20 December 2023) | Viewed by 32215
Special Issue Editor
Interests: brain-derived neurotrophic factor (BDNF); brain neural circuits; metabolic diseases; neurodegenerative diseases; neurodevelopmental disorders
Special Issue Information
Dear Colleagues,
The brain-derived neurotrophic factor (BDNF) was discovered as a growth factor promoting survival and growth of neurons. Since its discovery, BDNF has been shown to play an important role in an expanding list of biological processes from neuronal development, synaptic plasticity, and learning and memory to whole-body homeostasis of energy and glucose, as well as the pathophysiology and treatment of several neurological and psychiatric disorders.
The focus of this Special Issue of Biomolecules will be on articles that review recent advances in the role of BDNF in healthy and diseased brain, although original research articles are welcome. The covered topics will include but not be limited to the regulation of BDNF expression and secretion, BDNF-activated intracellular signaling cascades, and the roles of BDNF in the development and function of the healthy central nervous system, such as synaptogenesis, synaptic plasticity, cognition, and energy homeostasis. The discussion on the importance of BDNF in the pathophysiology and treatment of neurodevelopmental disorders (e.g., Rett syndrome), neurological disorders (e.g., Alzheimer’s disease and Huntington’s disease), and psychiatric disorders (e.g., anxiety and major depressive disorder) will also be included. Finally, articles on the novel roles of BDNF in glial cells and non-neuronal tissues are encouraged.
Prof. Dr. Baoji Xu
Guest Editor
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Keywords
- BDNF
- synaptic formation and plasticity
- neurodegenerative diseases
- major depressive disorder
- anxiety
- obesity
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