New Insights into Cytochrome P450s, 2nd Edition
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 1005
Special Issue Editor
Interests: enzymology; chemical biology; protein structure and dynamics; cytochrome P450; AlphaFold2
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cytochrome P450s form one of the most populated superfamilies of enzymes in nature. A recent search in the PDB with P450 as a keyword retrieved thousands of entries and 740,283 (highly redundant) entries in the UniProtKB database. Since their discovery in the late 1950s, these heme–thiolate proteins have been found in both prokaryotes and eukaryotes, with a few exceptions, such as E. coli. Recently, cytochrome P450s have also been spotted in viruses. Identification and functional studies have revealed that some P450s are specific to one substrate while others are able to accommodate a vast array of organic molecules while still differentiating a methyl from an ethyl group. In humans, some cytochrome P450s are involved in the critical metabolism of drug metabolism and pollutant detoxification. Others are involved in steroid and eicosanoid biosynthesis. In plants, most of the secondary metabolism pathways include one or several cytochrome P450s. Eukaryotic P450s, being membrane-bound, are difficult to crystallize. Most of them lack a known experimental 3D structure. The very recent advent of the deep-learning artificial intelligence AlphaFold2 and AlphaFold3 has opened fast access to the 3D structures of all membrane-bound P50s and of their complexes with associated redox proteins and effectors. Original manuscripts and reviews dealing with any aspect of cytochrome P450s and related aspects are welcome.
Dr. Philippe Urban
Guest Editor
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Keywords
- cytochrome P450 (P450)
- cytochrome b5
- NADPH-P450 oxidoreductase (CPR)
- heme
- flavin
- P450 structure
- P450 catalytic activities
- prokaryotic P450
- eukaryotic P450
- viral P450
- drug metabolism
- detoxification
- plant secondary metabolisms
- membrane protein–protein complex
- AlphaFold
- AlphaFold2
- regulation of P450 transcription
- catalytic cavities
- substrate access channels
- prediction of protein–protein complexes
- P450 interaction on P450–CPR complexes
- tripartite P450–CPR–cytochrome b5 complex
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