Emerging Role of Mitochondrial Reactive Oxygen Species in Cellular Signaling

Dear Colleagues,

Majima et al. were the first to report that reactive oxygen species (ROS) generated from mitochondria promote apoptosis (Majima et al., J Biol. Chem. 1998), while Itoh et al. described the function of the Nrf2-Keap1 intercellular signal for the first time (Itoh et al., Biochem. Biophys. Res. Commun. 1997, Itoh et al., Genes Dev. 1999). A recent study has described that ROS generated from mitochondria initiate cellular transduction in cytosol (Indo et al. Handb Exp Pharmacol. 2017). In this Special Issue, the further role of ROS and the subsequent intracellular signals, protein, and molecules’ transport-change will be clarified. The aim of this Special Issue is the establishment of cellular signaling and metabolism change based on mitochondrial ROS augmentation. Thus, the Special Issue explores the physiological and pathological new function of mitochondrial ROS.

Prof. Dr. Hideyuki J. Majima
Prof. Dr. Ken Itoh
Guest Editors

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