Molecular Mechanisms of DNA Damage in Mammalian Cells
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Nucleic Acids".
Deadline for manuscript submissions: closed (18 September 2021) | Viewed by 4452
Special Issue Editors
Interests: DNA; myosin; actin; transcription; DNA damage; molecular motors; mechanobiology; imaging
Special Issue Information
Dear Colleagues,
This Special Issue of Biomolecules (Impact Factor: 4.694) will cover all aspects of DNA damage covering the causes, types of damage and repair mechanisms.
The eukaryotic genome is continuously attacked by multiple factors causing a variety of DNA lesions. This includes exogenous agents, such as ultraviolet light, ionizing radiation and chemotherapeutic agents, and endogenous factors, such as the intracellular reactive oxygen species and alkylating agents. This leads to alterations in the DNA structure taking the form of nucleotide and base modifications, crosslinking, single-strand breaks and double-strand breaks.
Eukaryotic cells have evolved genome repair and surveillance mechanisms to specifically respond to the form of DNA damage. These fall under the pathways of base excision, nuclear excision, homology-directed and DNA mismatch repair, along with non-homologous end joining, amongst others. These pathways respond to the damage, regulate the cell cycle, alter chromatin and enable repair. If the damage exceeds the cell’s capability to repair then apoptosis pathways will be activated leading to cell death. Many classical chemotherapeutics take advantage of this response by inducing high levels of DNA damage that lead to cell death. Nevertheless, failure of this mechanism promotes genome instability which is linked to cancer development and other pathologies.
This Special Issue aims to collect a broad range of original and review articles focused on the mechanisms that lead to DNA damage and how it is repaired.
Dr. Christopher P. Toseland
Dr. Ália dos Santos
Guest Editors
Manuscript Submission Information
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Keywords
- DNA Damage
- DNA Repair
- Eukaryotic Genome
- Molecular Mechanisms
