Experimental and Bioinformatic Approaches for Biomarker Discovery in Disease: From Molecular Mechanisms to Therapeutic Challenges
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Bioinformatics and Systems Biology".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 11
Special Issue Editor
Interests: cancer biology; microRNAs; epigenetics; apoptosis and differentiation; platelets; inflammation; cell-to-cell crosstalk; bioactive lipids
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The discovery of biomarkers (genes, transcripts, proteins, metabolites, and non-coding regulatory RNAs) in disease is crucial for enhancing early detection, determining prognosis, selecting therapeutic strategies, and monitoring treatment response. In the past decade, advancements in molecular biology and bioinformatics have significantly accelerated the identification and validation of potential markers. This Special Issue delves into how experimental data, cutting-edge technologies, and computational tools can be integrated to elucidate the molecular mechanisms underlying specific diseases, thus leading to the discovery of novel biomarkers. Both experimental approaches and omics technologies have generated a wealth of biological data, often hindering our ability to understand the relationships between observed molecular changes and disease states, as well as interindividual variability. Bioinformatics analysis serves as a crucial bridge, enabling researchers to interpret data (from public repositories, research projects, and experimental studies) and identify significant molecular patterns, thereby providing a comprehensive understanding of the interaction networks involved in disease onset and progression. This multi-faceted approach is an indispensable prerequisite for translating basic scientific knowledge into clinical research, a process commonly referred to as the “bench-to-bedside” process. We believe that this proposed Special Issue offers a valuable resource for scientists, clinicians, and researchers interested in the forefront of biomarker research.
Dr. Valeria Gasperi
Guest Editor
Manuscript Submission Information
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Keywords
- biomarker
- molecular biology
- bioinformatics
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