Molecular Mechanisms of Plasticity Underpinning Disorders of the Nervous System

Dear Colleagues,

Plasticity is a critical process in the brain. It is defined as the ability of neurons to alter their strength of communication at synapses, and it underpins not only learning and memory, but also sensory and motor functions. Overall, plasticity processes in the brain have received much research attention, and increasing technological and resolution advances are enabling plasticity to be directly linked to in vivo behaviors. Importantly, it has been shown by many labs that changes in plasticity occur with neurodevelopmental and neurodegenerative disorders of the brain. Moreover, the rescue of normal plasticity processes can reverse clinical signs, at least in animal models. Identifying and characterizing the mechanisms that drive and underpin these pathological plasticity changes is imperative for new treatment strategies. In addition, the further development of key technologies and model systems that more closely mimic the human condition is imperative to enhance translation.

In this Special Issue of Biomolecules, we invite manuscript submissions addressing plasticity mechanisms in cellular and integrative disease models. The breadth of this Special Issue spans plasticity within the central and peripheral nervous systems, in either animal or human models of disease.

Dr. Johanna Montgomery
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.