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Serotonin Receptors and Their Interactions in Behavior Regulation and Other Physiological Roles

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A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 12991

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Special Issue Editor

Prof. Alexander V. Kulikov

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Guest Editor

Head of Department of Genetic Models of Neurological Disorders, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia
Interests: serotonin, STEP, behavior, neurogenomics, behavioral genetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The brain serotonin (5-HT) system regulates numerous physiological functions (such as immunity, endocrine function, body temperature, metabolism), kinds of behavior (such as locomotion, aggression, sleep, eating, sexual behavior) and psychic processes (such as emotion, cognition). This polyfunctionality is defined by 14 subtypes of the 5-HT receptors grouped into 7 types coupled with different mechanisms of signaling. Six types are coupled with Gi (5-HT1, 5-HT5), Gq (5-HT2) or Gs (5-HT4, 5-HT6, 5-HT7) proteins, while one type (5-HT3) forms Na+/K+-gated channels. 5-HT receptors, coupled with different mechanisms of signaling and coexpressed on the same neuron, interact in fine regulation of this neuron activity. Moreover, 5-HT receptors and neurotrophins interact in the mechanism of neuroplasticity. The functional activity of G protein-coupled 5-HT receptors is regulated by homo- and heterodimerization. Dysfunction and/or disbalance of 5-HT receptors, caused by genetic factors, stress or aging, result in nervous and psychiatric disorders, while agonists and antagonists of different 5-HT receptors can act as promising tools for their pharmacological correction. Original manuscripts and reviews dealing with any aspect of 5-HT receptor regulation or interactions between different types of 5-HT receptors in the mechanisms of normal and pathological manifestation of behavior and physiological functions are very welcome.

Prof. Alexander V. Kulikov
Guest Editor

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Keywords

serotonin receptors
modification
dimerization
interaction between receptors
thermoregulation
behavior regulation
psychiatric disorders
aging

Published Papers (4 papers)

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Research

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17 pages, 1458 KiB

Open AccessArticle

by Valentina S. Evsiukova, Elizabeth A. Kulikova and Alexander V. Kulikov

Biomolecules 2021, 11(10), 1421; https://doi.org/10.3390/biom11101421 - 28 Sep 2021

Cited by 7 | Viewed by 2119

Abstract

Short-lived turquoise killifish (Nothobranchius furzeri) have become a popular model organism for neuroscience. In the present paper we study for the first time their behavior in the novel tank diving test and the levels of mRNA of various 5-HT-related genes in brains of 2-, 4- and 6-month-old males and females of N. furzeri. The marked effect of age on body mass, locomotor activity and the mRNA level of Tph1b, Tph2, Slc6a4b, Mao, Htr1aa, Htr2a, Htr3a, Htr3b, Htr4, Htr6 genes in the brains of N. furzeri males was shown. Locomotor activity and expression of the Mao gene increased, while expression of Tph1b, Tph2, Slc6a4b, Htr1aa, Htr2a, Htr3a, Htr3b, Htr4, Htr6 genes decreased in 6-month-old killifish. Significant effects of sex on body mass as well as on mRNA level of Tph1a, Tph1b, Tph2, Slc6a4b, Htr1aa, 5-HT2a, Htr3a, Htr3b, Htr4, and Htr6 genes were revealed: in general both the body mass and the expression of these genes were higher in males. N. furzeri is a suitable model with which to study the fundamental problems of age-related alterations in various mRNA levels related with the brains 5-HT system. Full article

(This article belongs to the Special Issue Serotonin Receptors and Their Interactions in Behavior Regulation and Other Physiological Roles)

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22 pages, 2905 KiB

Open AccessFeature PaperArticle

Serotonin Signalling in Flatworms: An Immunocytochemical Localisation of 5-HT₇ Type of Serotonin Receptors in Opisthorchis felineus and Hymenolepis diminuta

by Natalia Kreshchenko, Nadezhda Terenina and Artem Ermakov

Biomolecules 2021, 11(8), 1212; https://doi.org/10.3390/biom11081212 - 15 Aug 2021

Cited by 5 | Viewed by 3117

Abstract

The study is dedicated to the investigation of serotonin (5-hydroxytryptamine, 5-HT) and 5-HT₇ type serotonin receptor of localisation in larvae of two parasitic flatworms Opisthorchis felineus (Rivolta, 1884) Blanchard, 1895 and Hymenolepis diminuta Rudolphi, 1819, performed using the immunocytochemical method and confocal laser scanning microscopy (CLSM). Using whole mount preparations and specific antibodies, a microscopic analysis of the spatial distribution of 5-HT₇-immunoreactivity(-IR) was revealed in worm tissue. In metacercariae of O. felineus 5-HT₇-IR was observed in the main nerve cords and in the head commissure connecting the head ganglia. The presence of 5-HT₇-IR was also found in several structures located on the oral sucker. 5-HT₇-IR was evident in the round glandular cells scattered throughout the larva body. In cysticercoids of H. diminuta immunostaining to 5-HT₇ was found in flame cells of the excretory system. Weak staining to 5-HT₇ was observed along the longitudinal and transverse muscle fibres comprising the body wall and musculature of suckers, in thin longitudinal nerve cords and a connective commissure of the central nervous system. Available publications on serotonin action in flatworms and serotonin receptors identification were reviewed. Own results and the published data indicate that the muscular structures of flatworms are deeply supplied by 5-HT₇-IR elements. It suggests that the 5-HT₇ type receptor can mediate the serotonin action in the investigated species and is an important component of the flatworm motor control system. The study of the neurochemical basis of parasitic flatworms can play an important role in the solution of fundamental problems in early development of the nervous system and the evolution of neuronal signalling components. Full article

(This article belongs to the Special Issue Serotonin Receptors and Their Interactions in Behavior Regulation and Other Physiological Roles)

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14 pages, 1905 KiB

Open AccessArticle

Memantine and Riluzole Exacerbate, Rather Than Ameliorate Behavioral Deficits Induced by 8-OH-DPAT Sensitization in a Spatial Task

by Martina Janikova, Karolina Mainerova, Iveta Vojtechova, Tomas Petrasek, Jan Svoboda and Ales Stuchlik

Biomolecules 2021, 11(7), 1007; https://doi.org/10.3390/biom11071007 - 9 Jul 2021

Cited by 3 | Viewed by 2596

Abstract

Chronic sensitization to serotonin 1A and 7 receptors agonist 8-OH-DPAT induces compulsive checking and perseverative behavior. As such, it has been used to model obsessive-compulsive disorder (OCD)-like behavior in mice and rats. In this study, we tested spatial learning in the 8-OH-DPAT model of OCD and the effect of co-administration of memantine and riluzole—glutamate-modulating agents that have been shown to be effective in several clinical trials. Rats were tested in the active place avoidance task in the Carousel maze, where they learned to avoid the visually imperceptible shock sector. All rats were subcutaneously injected with 8-OH-DPAT (0.25 mg/kg) or saline (control group) during habituation. During acquisition, they were pretreated with riluzole (1 mg/kg), memantine (1 mg/kg), or saline solution 30 min before each session and injected with 8-OH-DPAT (“OH” groups) or saline (“saline” groups) right before the experiment. We found that repeated application of 8-OH-DPAT during both habituation and acquisition significantly increased locomotion, but it impaired the ability to avoid the shock sector. However, the application of 8-OH-DPAT in habituation had no impact on the learning process if discontinued in acquisition. Similarly, memantine and riluzole did not affect the measured parameters in the “saline” groups, but in the “OH” groups, they significantly increased locomotion. In addition, riluzole increased the number of entrances and decreased the maximum time avoided of the shock sector. We conclude that monotherapy with glutamate-modulating agents does not reduce but exacerbates cognitive symptoms in the animal model of OCD. Full article

(This article belongs to the Special Issue Serotonin Receptors and Their Interactions in Behavior Regulation and Other Physiological Roles)

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Review

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46 pages, 1070 KiB

Open AccessReview

5-HT Receptors and Temperature Homeostasis

by Irina P. Voronova

Biomolecules 2021, 11(12), 1914; https://doi.org/10.3390/biom11121914 - 20 Dec 2021

Cited by 18 | Viewed by 4250

Abstract

The present review summarizes the data concerning the influence of serotonin (5-HT) receptors on body temperature in warm-blooded animals and on processes associated with its maintenance. This review includes the most important part of investigations from the first studies to the latest ones. The established results on the pharmacological activation of 5-HT_1A, 5-HT_3, 5-HT₇ and 5-HT₂ receptor types are discussed. Such activation of the first 3 type of receptors causes a decrease in body temperature, whereas the 5-HT₂ activation causes its increase. Physiological mechanisms leading to changes in body temperature as a result of 5-HT receptors’ activation are discussed. In case of 5-HT_1A receptor, they include an inhibition of shivering and non-shivering thermogenesis, as well simultaneous increase of peripheral blood flow, i.e., the processes of heat production and heat loss. The physiological processes mediated by 5-HT₂ receptor are opposite to those of the 5-HT_1A receptor. Mechanisms of 5-HT₃ and 5-HT₇ receptor participation in these processes are yet to be studied in more detail. Some facts indicating that in natural conditions, without pharmacological impact, these 5-HT receptors are important links in the system of temperature homeostasis, are also discussed. Full article

(This article belongs to the Special Issue Serotonin Receptors and Their Interactions in Behavior Regulation and Other Physiological Roles)

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