Visualizing the Genome
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Structure and Dynamics".
Deadline for manuscript submissions: closed (29 February 2020) | Viewed by 4139
Special Issue Editor
Special Issue Information
Dear Colleagues,
Genome organization plays an important role in biological processes such as cellular differentiation during development. Mis-regulation of proteins that govern genome architecture is often related to the progression of diseases, such as cancer or neurological disorders. In the past decade, advances in high-resolution imaging approaches, such as stimulated emission depletion (STED) and single-molecule localisation microscopy (SMLM), have led to the imaging of genome architecture well below the diffraction limit of light, allowing us to now dissect previously inaccessible dynamics critical to genome function. These developments have been complemented by approaches that allow us to determine genome architecture at the single-cell level based on the proximity of DNA sequences, such as single-cell chromosome conformation capture Hi-C. By bringing together these approaches, it has become clear that genome organisation varies considerably from cell to cell but that there are also emerging rules that govern this organisation, such as liquid–liquid phase separation of specific genomic sequences in the nucleus.
This Special Issue will present reviews and original articles covering advances in imaging, DNA proximity-based technology, and other approaches that improve our ability to visualize genome organization at the single-cell level, as well as how these advances have improved our understanding of the way genomes are organized.
Dr. Srinjan Basu
Guest Editor
Manuscript Submission Information
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Keywords
- imaging
- single-molecule
- high-resolution
- chromatin
- genome
- chromosome conformation capture
- fluorescence microscopy
- single-cell
