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Trends in Development of Biosensors for Disease Diagnosis, Treatment and...
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Trends in Development of Biosensors for Disease Diagnosis, Treatment and Management—2nd Edition

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 4297

Special Issue Editor

Dr. Amir Hatamie

E-Mail Website
Guest Editor
Department of Chemistry and Molecular Biology, University of Gothenburg, 41296 Gothenburg, Sweden
Interests: nano/microscale sensors; nanopore electrode; single-cell analysis; intracellular analysis; sensors for cell- and brain-tissue engineering; bioelectrochemistry; 2D materials for sensing applications; wearable (bio)sensors; flexible electrochemical sensors; (bio)sensors in plant science
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

After the successful publication of the first edition of this Special Issue, entitled "Trends in Development of Biosensors for Disease Diagnosis, Treatment, and Management", we are pleased to announce the launch of the second edition under the same name. In recent years, biosensor development has garnered significant attention in the fields of biomedicine and healthcare. Biosensors find wide-ranging applications in disease diagnosis, treatment, patient health monitoring, and human health management.

For this Special Issue, our focus will be on innovative and groundbreaking biosensing technologies, which encompass electrochemical and optical biosensors, flexible biosensors, wearable technologies, paper-based detection strategies, microfluidic biosensors, gas detection biosensors, enzymatic biosensors, and micro–nano-scale biosensors. We also emphasize the importance of unique materials, nanomaterials, and sensor components, such as aptamers, smart polymers, imprinted polymers, metamaterials, 2D and 3D nanomaterials, among others.

Furthermore, our interest extends to novel biomarkers, such as exosomes, microRNA, RNAs, and DNAs, which are present in various biological samples, including tears, sweat, saliva, blood, urine, and even breath. These topics offer opportunities for advancing research and enhancing disease diagnosis or treatment processes, resulting in quicker and more precise diagnostic outcomes.

We eagerly welcome research articles, review articles and communications. For those planning to submit papers, you may send a title and a concise abstract (approximately 100 words) to the Editorial Office or submit them on the Special Issue’s website. Please visit the Instructions for Authors page for detailed submission guidelines.

Dr. Amir Hatamie
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanobiosensors for biomedical applications
  • nanomaterials in biosensors
  • disease diagnosis
  • biomarker detection
  • cellular analysis and diagnostics
  • point-of-care diagnostics
  • clinical analysis

Published Papers (3 papers)

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Research

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13 pages, 2488 KiB  
Article
Reagentless Glucose Biosensor Based on Combination of Platinum Nanostructures and Polypyrrole Layer
by Natalija German, Anton Popov and Almira Ramanaviciene
Biosensors 2024, 14(3), 134; https://doi.org/10.3390/bios14030134 - 4 Mar 2024
Viewed by 1350
Abstract
Two types of low-cost reagentless electrochemical glucose biosensors based on graphite rod (GR) electrodes were developed. The electrodes modified with electrochemically synthesized platinum nanostructures (PtNS), 1,10-phenanthroline-5,6-dione (PD), glucose oxidase (GOx) without and with a polypyrrole (Ppy) layer—(i) GR/PtNS/PD/GOx and (ii) GR/PtNS/PD/GOx/Ppy, respectively, were [...] Read more.
Two types of low-cost reagentless electrochemical glucose biosensors based on graphite rod (GR) electrodes were developed. The electrodes modified with electrochemically synthesized platinum nanostructures (PtNS), 1,10-phenanthroline-5,6-dione (PD), glucose oxidase (GOx) without and with a polypyrrole (Ppy) layer—(i) GR/PtNS/PD/GOx and (ii) GR/PtNS/PD/GOx/Ppy, respectively, were prepared and tested. Glucose biosensors based on GR/PtNS/PD/GOx and GR/PtNS/PD/GOx/Ppy electrodes were characterized by the sensitivity of 10.1 and 5.31 μA/(mM cm2), linear range (LR) up to 16.5 and 39.0 mM, limit of detection (LOD) of 0.198 and 0.561 mM, good reproducibility, and storage stability. The developed glucose biosensors based on GR/PtNS/PD/GOx/Ppy electrodes showed exceptional resistance to interfering compounds and proved to be highly efficient for the determination of glucose levels in blood serum. Full article
(This article belongs to the Special Issue Trends in Development of Biosensors for Disease Diagnosis, Treatment and Management—2nd Edition)
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Review

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13 pages, 7891 KiB  
Review
Fueling the Future: The Emergence of Self-Powered Enzymatic Biofuel Cell Biosensors
by Akhilesh Kumar Gupta and Alexey Viktorovich Krasnoslobodtsev
Biosensors 2024, 14(7), 316; https://doi.org/10.3390/bios14070316 - 24 Jun 2024
Viewed by 504
Abstract
Self-powered biosensors are innovative devices that can detect and analyze biological or chemical substances without the need for an external power source. These biosensors can convert energy from the surrounding environment or the analyte itself into electrical signals for sensing and data transmission. [...] Read more.
Self-powered biosensors are innovative devices that can detect and analyze biological or chemical substances without the need for an external power source. These biosensors can convert energy from the surrounding environment or the analyte itself into electrical signals for sensing and data transmission. The self-powered nature of these biosensors offers several advantages, such as portability, autonomy, and reduced waste generation from disposable batteries. They find applications in various fields, including healthcare, environmental monitoring, food safety, and wearable devices. While self-powered biosensors are a promising technology, there are still challenges to address, such as improving energy efficiency, sensitivity, and stability to make them more practical and widely adopted. This review article focuses on exploring the evolving trends in self-powered biosensor design, outlining potential advantages and limitations. With a focal point on enzymatic biofuel cell power generation, this article describes various sensing mechanisms that employ the analyte as substrate or fuel for the biocatalyst’s ability to generate current. Technical aspects of biofuel cells are also examined. Research and development in the field of self-powered biosensors is ongoing, and this review describes promising areas for further exploration within the field, identifying underexplored areas that could benefit from further investigation. Full article
(This article belongs to the Special Issue Trends in Development of Biosensors for Disease Diagnosis, Treatment and Management—2nd Edition)
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32 pages, 6840 KiB  
Review
Advancements in Brain Research: The In Vivo/In Vitro Electrochemical Detection of Neurochemicals
by Xiaoxuan Xu, Yimei Zuo, Shu Chen, Amir Hatami and Hui Gu
Biosensors 2024, 14(3), 125; https://doi.org/10.3390/bios14030125 - 26 Feb 2024
Viewed by 2067
Abstract
Neurochemicals, crucial for nervous system function, influence vital bodily processes and their fluctuations are linked to neurodegenerative diseases and mental health conditions. Monitoring these compounds is pivotal, yet the intricate nature of the central nervous system poses challenges. Researchers have devised methods, notably [...] Read more.
Neurochemicals, crucial for nervous system function, influence vital bodily processes and their fluctuations are linked to neurodegenerative diseases and mental health conditions. Monitoring these compounds is pivotal, yet the intricate nature of the central nervous system poses challenges. Researchers have devised methods, notably electrochemical sensing with micro-nanoscale electrodes, offering high-resolution monitoring despite low concentrations and rapid changes. Implantable sensors enable precise detection in brain tissues with minimal damage, while microdialysis-coupled platforms allow in vivo sampling and subsequent in vitro analysis, addressing the selectivity issues seen in other methods. While lacking temporal resolution, techniques like HPLC and CE complement electrochemical sensing’s selectivity, particularly for structurally similar neurochemicals. This review covers essential neurochemicals and explores miniaturized electrochemical sensors for brain analysis, emphasizing microdialysis integration. It discusses the pros and cons of these techniques, forecasting electrochemical sensing’s future in neuroscience research. Overall, this comprehensive review outlines the evolution, strengths, and potential applications of electrochemical sensing in the study of neurochemicals, offering insights into future advancements in the field. Full article
(This article belongs to the Special Issue Trends in Development of Biosensors for Disease Diagnosis, Treatment and Management—2nd Edition)
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