Advances in Neuroinflammation and Pain Medicine

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuroscience of Pain".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 1149

Special Issue Editors


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Guest Editor
Pain Neuroimmunobiology Laboratory, Institute of Motricity Sciences, Federal University of Alfenas, Alfenas 37130-001, MG, Brazil
Interests: pain; analgesia; neuroinflammation; neuroimmune response; glial cells; pharmacology; physiology
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Guest Editor
Multicenter Graduate Program in Physiological Sciences, Institute of Biomedical Sciences - PPGMCF-ICB), Federal University of Alfenas, Alfenas 37130-001, MG, Brazil
Interests: pain; endocannabinoid signaling; fear-related disorders; neural circuits

Special Issue Information

Dear Colleagues,

Recently, science has demonstrated that a specific relationship exists between the immune system and the development of pain. In this context, studies involving the investigation of neuroinflammation have been of great interest to pain medicine, both for unveiling new mechanisms of action and the development of treatment strategies.

Present in the scientific literature are articles elucidating mechanisms involved in the neuroinflammatory responses to different types of pain, as well as treatment strategies for controlling these mechanisms and, consequently, the associated pain.

We are focusing on devising strategies that allow scientific innovation, mainly through new tools, technologies, and studies that help us to uncover mechanisms involved in neuroinflammation and pain medicine.

Authors are invited to submit relevant original research articles, as well as reviews and systematic review articles.

Dr. Giovane S. Galdino
Dr. Tayllon dos Anjos-Garcia
Guest Editors

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Keywords

  • pain medicine
  • neuroinflammation
  • immune system
  • nociception
  • pain treatment
  • analgesia

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Published Papers (1 paper)

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Review

14 pages, 3834 KiB  
Review
The Role of the Thalamus in Nociception: Important but Forgotten
by Giovane Galdino, Flavio Protasio Veras and Tayllon dos Anjos-Garcia
Brain Sci. 2024, 14(8), 741; https://doi.org/10.3390/brainsci14080741 - 25 Jul 2024
Viewed by 864
Abstract
Pain is a complex response to noxious stimuli. Upon detection of the nociceptive stimulus by first-order neurons or nociceptors, an action potential ascends to the spinal dorsal horn, a crucial site for synapsing with second-order neurons. These second-order neurons carry the nociceptive stimulus [...] Read more.
Pain is a complex response to noxious stimuli. Upon detection of the nociceptive stimulus by first-order neurons or nociceptors, an action potential ascends to the spinal dorsal horn, a crucial site for synapsing with second-order neurons. These second-order neurons carry the nociceptive stimulus to supraspinal regions, notably the thalamus. Although extensive research has focused on spinal-level nociceptive mechanisms (e.g., neurotransmitters, receptors, and glial cells), the thalamus is still poorly elucidated. The role of the thalamus in relaying sensory and motor responses to the cortex is well known. However, a comprehensive understanding of the mechanisms in the synapse between the second-order and third-order neurons that transmit this impulse to the somatosensory cortex, where the response is processed and interpreted as pain, is still lacking. Thus, this review investigated the thalamus’s role in transmitting nociceptive impulses. Current evidence indicates the involvement of the neurotransmitters glutamate and serotonin, along with NMDA, P2X4, TLR4, FGR, and NLRP3 receptors, as well as signaling pathways including ERK, P38, NF-κB, cytokines, and glial cells at nociceptive synapses within the thalamus. Full article
(This article belongs to the Special Issue Advances in Neuroinflammation and Pain Medicine)
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