Stress, Resilience and Susceptibility

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuropharmacology and Neuropathology".

Deadline for manuscript submissions: 15 May 2025 | Viewed by 1742

Special Issue Editor


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Guest Editor
Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal 59078-900, RN, Brazil
Interests: animal models; rodents; stress; depression; anxiety; hippocampus; neuropeptides

Special Issue Information

Dear Colleagues,

Stress is a common reaction to environmental adversity, but while it is essential for the maintenance of homeostasis and survival, maladaptive responses to stress insults can lead to mental disorders and unhealthy conditions. The ability to adapt to a stressful condition and not develop a pathological state is termed “resilience”. Significant efforts have been made to understand the neurobiological basis of psychiatric disorders and the influence of life events on risk and resilience. Additionally, new strategies to prevent the onset of stress-induced psychopathologies by increasing stress resilience in high-risk populations have generated great interest. This view has encouraged a number of studies searching for the mechanisms underlying stress resilience and how they can be used to increase resilience in vulnerable individuals.

This Special Issue welcomes original and review articles related to stress resilience and susceptibility in order to shed light on the scientific discussion about the neurobiological mechanisms, biomarkers, innovative pharmacological targets and clinical interventions to increase resilience in vulnerable individuals.

  • Neurobiological mechanisms;
  • Biomarkers of stress resilience and susceptibility;
  • Pharmacology of stress resilience and susceptibility;
  • Animal models for studying resilience and susceptibility to stress;
  • Psychiatric disorders associated with resilience and susceptibility to stress;
  • Clinical interventions to increase resilience to stress.

Dr. Elaine Gavioli
Guest Editor

Manuscript Submission Information

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Keywords

  • stress
  • resilience
  • vulnerability
  • psychiatric disorders
  • biomarkers

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Published Papers (1 paper)

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Review

23 pages, 747 KiB  
Review
Effects of Stress Exposure to Pain Perception in Pre-Clinical Studies: Focus on the Nociceptin/Orphanin FQ–NOP Receptor System
by Pietro Pola, Alessia Frezza, Elaine C. Gavioli, Girolamo Calò and Chiara Ruzza
Brain Sci. 2024, 14(9), 936; https://doi.org/10.3390/brainsci14090936 - 19 Sep 2024
Viewed by 1290
Abstract
Exposure to physical and psychological stress modulates pain transmission in a dual manner. Stress-induced analgesia (SIA) refers to the reduction in pain sensitivity that can occur in response to acute stress. On the contrary, chronic stress exposure may lead to a phenomenon named [...] Read more.
Exposure to physical and psychological stress modulates pain transmission in a dual manner. Stress-induced analgesia (SIA) refers to the reduction in pain sensitivity that can occur in response to acute stress. On the contrary, chronic stress exposure may lead to a phenomenon named stress-induced hyperalgesia (SIH). SIH is a clinically relevant phenomenon since it has been well documented that physical and psychological stress exacerbates pain in patients with several chronic pain syndromes, including migraine. The availability of animal models of SIA and SIH is of high importance for understanding the biological mechanisms leading to these phenomena and for the identification of pharmacological targets useful to alleviate the burden of stress-exacerbated chronic pain. Among these targets, the nociceptin/orphanin FQ (N/OFQ)–N/OFQ peptide (NOP) receptor system has been identified as a key modulator of both pain transmission and stress susceptibility. This review describes first the experimental approaches to induce SIA and SIH in rodents. The second part of the manuscript summarizes the scientific evidence that suggests the N/OFQ–NOP receptor system as a player in the stress–pain interaction and candidates NOP antagonists as useful drugs to mitigate the detrimental effects of stress exposure on pain perception. Full article
(This article belongs to the Special Issue Stress, Resilience and Susceptibility)
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