New Insights into Molecular Mechanisms Underlying Neurodegenerative Disorders
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".
Deadline for manuscript submissions: closed (2 July 2022) | Viewed by 53425
Special Issue Editors
Interests: neuroinflammation; neuro-oncology; neurodegeneration; epigenetics; histone modifications; signal transduction; transcription factors
Special Issues, Collections and Topics in MDPI journals
Interests: genetics; Alzheimer’s disease; non-coding RNAs; neurodegeneration; epilepsy; brain; biomarkers
Special Issues, Collections and Topics in MDPI journals
Interests: Neurodegeneration; Neurological disorders; HMGB1 protein; Epilepsy; Parkinson disease; Alzheimer disease
Special Issue Information
Dear Colleagues,
Neurodegenerative disorders encompass a broad range of sporadic and/or familial debilitating conditions characterized by the progressive dysfunction and loss of selective neuronal populations, determining different clinical phenotypes. Emerging research data indicate an interplay of genetic factors and epigenetic mechanisms underlying neurodegenerative processes, which lead to increased prevalence of neurodegenerative disorders. In concert with the constant increase in the aging population, neurodegenerative disorders currently represent a major challenge to public health worldwide.
Despite recent advances in clinical and preclinical research, the pathogenesis of these disorders still remains poorly understood, without effective treatments being available to halt the neurodegenerative processes, but rather aiming at relieving symptoms. Therefore, a critical evaluation of current research data and in depth understanding of the molecular mechanisms that lead to neurodegeneration is crucial in order to identify potential therapeutic targets that can pave the way to the development of novel and promising therapies.
This Special Issue is focused on novel molecular data in the field of neurodegeneration that associate with the onset and progression of neurodegenerative diseases. We are particularly interested in original articles and reviews that provide new insights into the main molecular pathogenic mechanisms underlying neurodegenerative disorders, aiming to identify potential biomarkers and novel therapeutic strategies.
Prof. Dr. Christina Piperi
Dr. Chiara Villa
Dr. Yam Nath Paudel
Guest Editors
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Keywords
- neurodegeneration
- Alzheimer’s disease
- Parkinson’s disease
- amyotrophic lateral sclerosis
- multiple sclerosis
- Huntington’s disease
- motor neuron disease
- biomarkers
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