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Cancers
Special Issues
Surgical Innovations in Gynecologic Oncology: Endometrial and Ovarian Cancer
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Surgical Innovations in Gynecologic Oncology: Endometrial and Ovarian Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 29 November 2024 | Viewed by 2829

Special Issue Editors

Dr. Nicolae Bacalbașa

E-Mail Website
Guest Editor
1. Faculty of Medicine, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, Romania 2. Department of Visceral Surgery, Center of Excellence in Translational Medicine, Fundeni Clinical Institute, 022328 Bucharest, Romania
Interests: ovarian cancer; gynecologic surgery; gynecologic oncology
Dr. Valentin Nicolae Varlas

E-Mail Website
Guest Editor
Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 010221 Bucharest, Romania
Interests: gynecologic oncology; gynecologic cancer surgery; minimally invasive surgery; immunology and genetics of tumors; endometriosis; oncofertility
Special Issues, Collections and Topics in MDPI journals
Dr. Irina Balescu

E-Mail Website
Guest Editor
Department of Surgery, Ponderas Academic Hospital, 021188 Bucharest, Romania
Interests: surgical oncology; hepato-bilio-pancreatic surgery; gynecologic oncology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gynecological malignancies still represent significant health problems affecting women worldwide, especially when diagnosed in advanced stages of the disease. While, in endometrial cancer, alarming signs and symptoms, such as postmenopausal vaginal bleeding, might motivate a patient to seek medical help, in ovarian cancer the diagnosis usually occurs in advanced stages of the disease due to the fact that uncommon symptoms are present. In this respect, attention was focused on identifying new surgical procedures, new lines of targeted therapies, and genetic counseling in order to improve the long-term outcomes of these patients. Therefore, nowadays, the golden standard in such cases, consisting of debulking surgery to no residual disease, should be strongly reinforced by adding targeted therapies and genetic counseling. The aim of the current Special Issue is to highlight the surgical and oncological therapies in endometrial and ovarian cancer.

Dr. Nicolae Bacalbașa
Dr. Valentin Nicolae Varlas
Dr. Irina Balescu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometrial cancer
  • ovarian cancer
  • personalized medicine
  • debulking surgery
  • molecular therapies
  • genetic counseling
  • high-grade tumors

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Published Papers (2 papers)

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18 pages, 2343 KiB  
Article
The Influence of Inflammatory and Nutritional Status on the Long-Term Outcomes in Advanced Stage Ovarian Cancer
by Nicolae Bacalbasa, Sorin Petrea, Bogdan Gaspar, Lucian Pop, Valentin Varlas, Adrian Hasegan, Gabriel Gorecki, Cristina Martac, Marilena Stoian, Anca Zgura and Irina Balescu
Cancers 2024, 16(14), 2504; https://doi.org/10.3390/cancers16142504 - 10 Jul 2024
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Abstract
Background: Despite improving surgical techniques and achieving more often complete debulking procedures, certain patients with advanced-stage ovarian cancer still have a very poor prognosis. The aim of the current paper is to investigate whether inflammatory and nutritional status can predict the long-term outcomes [...] Read more.
Background: Despite improving surgical techniques and achieving more often complete debulking procedures, certain patients with advanced-stage ovarian cancer still have a very poor prognosis. The aim of the current paper is to investigate whether inflammatory and nutritional status can predict the long-term outcomes of ovarian cancer patients. Methods: A retrospective analysis of 57 cases diagnosed with advanced-stage ovarian cancer submitted to surgery as first intent therapy was carried out. In all cases, the preoperative status was determined by calculating the CRP/albumin ratio, as well as the Glasgow score, the modified Glasgow score and the prognostic nutritional index. Results: Patients presenting higher values of the CRP/albumin ratio, with a higher Glasgow score, modified Glasgow score and prognostic nutritional index (PNI), were more frequently associated with incomplete debulking surgery, a higher peritoneal carcinomatosis index and poorer overall survival (20 months versus 9 months for the CRP/albumin ratio p = 0.011, 42 versus 27 versus 12 months for the Glasgow score p = 0.042, 50 versus 19 versus 12 months for the modified Glasgow score, p = 0.001, and 54 months versus 21 months, p = 0.011 for the prognostic nutritional index). Conclusions: A strong relationship between the nutritional and inflammatory status in advanced-stage ovarian cancer seems to exist. Full article
(This article belongs to the Special Issue Surgical Innovations in Gynecologic Oncology: Endometrial and Ovarian Cancer)
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29 pages, 2343 KiB  
Systematic Review
Surgical Treatment for Endometrial Cancer, Hysterectomy Performed via Minimally Invasive Routes Compared with Open Surgery: A Systematic Review and Network Meta-Analysis
by Purushothaman Natarajan, Gayathri Delanerolle, Lucy Dobson, Cong Xu, Yutian Zeng, Xuan Yu, Kathleen Marston, Thuan Phan, Fiona Choi, Vanya Barzilova, Simon G. Powell, James Wyatt, Sian Taylor, Jian Qing Shi and Dharani K. Hapangama
Cancers 2024, 16(10), 1860; https://doi.org/10.3390/cancers16101860 - 13 May 2024
Cited by 1 | Viewed by 1746
Abstract
Background: Total hysterectomy with bilateral salpingo-oophorectomy via minimally invasive surgery (MIS) has emerged as the standard of care for early-stage endometrial cancer (EC). Prior systematic reviews and meta-analyses have focused on outcomes reported solely from randomised controlled trials (RCTs), overlooking valuable data [...] Read more.
Background: Total hysterectomy with bilateral salpingo-oophorectomy via minimally invasive surgery (MIS) has emerged as the standard of care for early-stage endometrial cancer (EC). Prior systematic reviews and meta-analyses have focused on outcomes reported solely from randomised controlled trials (RCTs), overlooking valuable data from non-randomised studies. This inaugural systematic review and network meta-analysis comprehensively compares clinical and oncological outcomes between MIS and open surgery for early-stage EC, incorporating evidence from randomised and non-randomised studies. Methods: This study was prospectively registered on PROSPERO (CRD42020186959). All original research of any experimental design reporting clinical and oncological outcomes of surgical treatment for endometrial cancer was included. Study selection was restricted to English-language peer-reviewed journal articles published 1 January 1995–31 December 2021. A Bayesian network meta-analysis was conducted. Results: A total of 99 studies were included in the network meta-analysis, comprising 181,716 women and 14 outcomes. Compared with open surgery, laparoscopic and robotic-assisted surgery demonstrated reduced blood loss and length of hospital stay but increased operating time. Compared with laparoscopic surgery, robotic-assisted surgery was associated with a significant reduction in ileus (OR = 0.40, 95% CrI: 0.17–0.87) and total intra-operative complications (OR = 0.38, 95% CrI: 0.17–0.75) as well as a higher disease-free survival (OR = 2.45, 95% CrI: 1.04–6.34). Conclusions: For treating early endometrial cancer, minimal-access surgery via robotic-assisted or laparoscopic techniques appears safer and more efficacious than open surgery. Robotic-assisted surgery is associated with fewer complications and favourable oncological outcomes. Full article
(This article belongs to the Special Issue Surgical Innovations in Gynecologic Oncology: Endometrial and Ovarian Cancer)
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