Stem Cells and Cancer Stem Cells: Similarities and Differences
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: closed (21 September 2023) | Viewed by 241
Special Issue Editors
Interests: Wnt signaling; differential Kat3 coactivator usage; stem cells and cancer stem cells; aging; chemical genomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
From the standpoint of safely targeting CSCs, it appears that the similarities between normal adult SSCs and CSCs far outweigh the differences between them. This is not all that surprising, in that CSCs likely arise from SSCs in many instances. Importantly, by the definition of “stemness,” they both have the ability to self-renew and also proceed on to more differentiated cell types. CSCs express similar “stemness” markers and exhibit cellular behaviors highly reminiscent of SSCs. Long-lived quiescent SSCs infrequently enter the cell cycle to maintain homeostasis, but more frequently upon injury to repair damaged tissue. This process seems to be degraded with aging.
Similarly, CSCs appear to reside in similar niches to SSCs and in fact can compete with one another for the limited space within the niche. The same signaling pathways involved in regulating SSC maintenance (i.e., Wnt, Notch, Hedeghog, TGFβ/BMP, JAK/Stat, Hippo, FGF/MAPK/PI3K) are also involved in the regulation of CSCs. Aberrant regulation of these same pathways leads to neoplastic proliferation in the same tissues.
The focus of this review will be on the fundamental similarities and differences between normal adult SSCs and CSCs and how we may be able to safely target defective stem cells/cancer stem cells.
Prof. Dr. Michael Kahn
Prof. Dr. Yoichi Furukawa
Guest Editors
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Keywords
- somatic stem cells
- cancer stem cells
- microenvironment
- metabolism
- therapy resistance
- quiescence
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