Advances in the Use of PET/CT and MRI in Prostate Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 894

Special Issue Editor


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Guest Editor
Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS-Università Cattolica del Sacro Cuore, Rome, Italy
Interests: prostate cancer; PET/CT; molecular imaging; oncology

Special Issue Information

Dear Colleagues,

The early detection of lymph node and distant organ metastases from prostate cancer at initial staging, especially for restaging when persistence or recurrence is suspected, represents one of the most interesting challenges in modern medicine. The most recent advancements in PET/CT and MRI serve this purpose well, thanks to the development of even higher performing and more specific radiopharmaceuticals for PET/CT imaging, along with the use of multi-parametric MRI, including diffusion-weighted and post-contrast dynamic sequences and spectroscopy. An even earlier definition of overall disease status enables the application of the most correct treatment for the individual patient, with an undeniable impact on prognosis.  

This Special Issue, entitled “Advances in the Use of PET/CT and MRI in Prostate Cancer”, will focus on the role of the most recent advancements in PET/CT and MRI in the management of patients affected by prostate cancer, for initial staging and restaging purposes. Moreover, the advanced analysis of PET/CT and MRI using radiomics enables the extraction of otherwise concealed information from images, potentially useful for therapeutic and diagnostic management. Finally, PET/CT may act as guidance to provide indications for therapy with novel receptor-targeted radiopharmaceuticals and to assess its effectiveness.  

Dr. Carmelo Caldarella
Guest Editor

Manuscript Submission Information

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Keywords

  • PET/CT
  • MRI
  • prostate cancer
  • radiomic
  • receptor-targeted radiopharmaceuticals

Published Papers (1 paper)

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Research

10 pages, 535 KiB  
Article
Assessment of PSMA Expression of Healthy Organs in Different Stages of Prostate Cancer Using [68Ga]Ga-PSMA-11-PET Examinations
by Holger Einspieler, Kilian Kluge, David Haberl, Katrin Schatz, Lukas Nics, Stefan Schmitl, Barbara Katharina Geist, Clemens P. Spielvogel, Bernhard Grubmüller, Pascal A. T. Baltzer, Gero Kramer, Shahrokh F. Shariat, Marcus Hacker and Sazan Rasul
Cancers 2024, 16(8), 1514; https://doi.org/10.3390/cancers16081514 - 16 Apr 2024
Viewed by 658
Abstract
The efficacy of radioligand therapy (RLT) targeting prostate-specific membrane antigen (PSMA) is currently being investigated for its application in patients with early-stage prostate cancer (PCa). However, little is known about PSMA expression in healthy organs in this cohort. Collectively, 202 [68Ga]Ga-PSMA-11 [...] Read more.
The efficacy of radioligand therapy (RLT) targeting prostate-specific membrane antigen (PSMA) is currently being investigated for its application in patients with early-stage prostate cancer (PCa). However, little is known about PSMA expression in healthy organs in this cohort. Collectively, 202 [68Ga]Ga-PSMA-11 positron emission tomography (PET) scans from 152 patients were studied. Of these, 102 PET scans were from patients with primary PCa and hormone-sensitive biochemically recurrent PCa and 50 PET scans were from patients with metastatic castration-resistant PCa (mCRPC) before and after three cycles of [177Lu]Lu-PSMA-RLT. PSMA-standardized uptake values (SUV) were measured in multiple organs and PSMA-total tumor volume (PSMA-TTV) was determined in all cohorts. The measured PET parameters of the different cohorts were normalized to the bloodpool and compared using t- or Mann–Whitney U tests. Patients with early-stage PCa had lower PSMA-TTVs (10.39 mL vs. 462.42 mL, p < 0.001) and showed different SUVs in the thyroid, submandibular glands, heart, liver, kidneys, intestine, testes and bone marrow compared to patients with advanced CRPC, with all tests showing p < 0.05. Despite the differences in the PSMA-TTV of patients with mCRPC before and after [177Lu]Lu-PSMA-RLT (462.42 mL vs. 276.29 mL, p = 0.023), no significant organ differences in PET parameters were detected. These suggest different degrees of PSMA-ligand binding among patients with different stages of PCa that could influence radiotoxicity during earlier stages of disease in different organs when PSMA-RLT is administered. Full article
(This article belongs to the Special Issue Advances in the Use of PET/CT and MRI in Prostate Cancer)
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