Bio-Pathological Markers for the Diagnosis and Therapy of Cancers, 3rd Edition

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".

Deadline for manuscript submissions: 15 March 2025 | Viewed by 597

Special Issue Editor


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Guest Editor
Department of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia” Anatomic Pathology, University of Catania, 95123 Catania, Italy
Interests: neuropathology; surgical pathology; uveal melanoma; immunohistochemistry; dermatopathology; oncology
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Special Issue Information

Dear Colleagues,

The search for biological factors that may have a prognostic value or act as predictors of therapeutic response still represents one of the hottest fields in human cancer research. Nevertheless, new immunohistochemical or molecular markers that can improve diagnostic accuracy in clinical practice and make it more reproducible are constantly being studied.

This Special Issue is devoted to the study of new diagnostic tools and prognostic/predictive factors in human neoplasms. Manuscripts in which this topic is approached by immunohistochemistry (IHC) as a first step are particularly welcome, but, being aware of the strengths and limits of IHC, the use of other methods (e.g., Western blot, FISH, or next-generation sequencing) is also encouraged.

Authors should demonstrate the impact of their findings in their works in combination with the morphological evaluation of histologic samples.

Clinicopathological studies, in vitro and in vivo studies with cell culture and animals, and manuscripts in which immunohistochemical findings are supported by molecular ones are particularly welcome. A limited number of relevant case reports will also be considered for publication.

Dr. Giuseppe Broggi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prognostic and predictive factors
  • cancer
  • immunohistochemistry
  • molecular biology
  • cellular markers
  • diagnosis
  • immunomarkers

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Published Papers (1 paper)

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Review

17 pages, 1653 KiB  
Review
H3K27me3 Loss in Central Nervous System Tumors: Diagnostic, Prognostic, and Therapeutic Implications
by Giuseppe Angelico, Manuel Mazzucchelli, Giulio Attanasio, Giordana Tinnirello, Jessica Farina, Magda Zanelli, Andrea Palicelli, Alessandra Bisagni, Giuseppe Maria Vincenzo Barbagallo, Francesco Certo, Maurizio Zizzo, Nektarios Koufopoulos, Gaetano Magro, Rosario Caltabiano and Giuseppe Broggi
Cancers 2024, 16(20), 3451; https://doi.org/10.3390/cancers16203451 - 11 Oct 2024
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Abstract
Central nervous system (CNS) tumors represent a formidable clinical challenge due to their molecular complexity and varied prognostic outcomes. This review delves into the pivotal role of the epigenetic marker H3K27me3 in the development and treatment of CNS tumors. H3K27me3, specifically the trimethylation [...] Read more.
Central nervous system (CNS) tumors represent a formidable clinical challenge due to their molecular complexity and varied prognostic outcomes. This review delves into the pivotal role of the epigenetic marker H3K27me3 in the development and treatment of CNS tumors. H3K27me3, specifically the trimethylation of lysine 27 on the histone H3 protein, plays a crucial role in regulating gene expression and maintaining chromatin architecture (e.g., in X-chromosome inactivation). Notably, a reduction in H3K27me3 levels, frequently tied to mutations in the H3 gene family such as H3F3A and HIST1H3B, is evident in diverse brain tumor variants, including the diffuse midline glioma characterized by the H3K27M mutation and certain pediatric high-grade gliomas. The loss of H3K27me3 has been linked to more aggressive behavior in meningiomas, with the trimethylation loss associated with significantly shorter recurrence-free survival (RFS) among grade 2 meningiomas, albeit not within grade 1 tumors. Pediatric posterior fossa ependymomas characterized by a lowered H3K27me3 and DNA hypomethylation exhibit poor prognosis, underscoring the prognostic significance of these epigenetic alterations in CNS tumors. Comprehending the role of H3K27me3 in CNS tumors is vital for advancing diagnostic tools and therapeutic interventions, with the goal of enhancing patient outcomes and quality of life. This review underscores the importance of ongoing investigations into H3K27me to refine and optimize management strategies for CNS tumors, paving the way for improved personalized medicine practices in oncology. Full article
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