Novel Approaches to Gynecologic Cancers Biology and Treatment

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 700

Special Issue Editors


E-Mail Website
Guest Editor
Ist Chair and Department of Gynecologic Oncology and Gynecology, Medical University of Lublin, Lublin, Poland
Interests: gynecology; gynecologic oncology; uterine sarcoma; endometrial cancer; cancer immunology; chemosensitivity; tumor microenvironment; target therapy; angiogenesis; lymphangiogenesis

E-Mail Website
Co-Guest Editor
Ist Chair and Department of Gynecologic Oncology and Gynecology, Medical University of Lublin, Lublin, Poland
Interests: gynecology; endometriosis; immunity; hormonal therapy; cancer risk factors

Special Issue Information

Dear Colleagues,

In recent years, rapid developments in both basic and clinical research have been observed in the field of gynecologic oncology. Multiple therapeutic methods have been introduced and developed, deeply altering the landscape of female genital cancer treatment. 

Nowadays, we can offer our patients a variety of targeted treatments, from immunotherapy, PARP inhibitors, anti- angiogenic drugs, to microinvasive surgeries. Multiple novel drugs and methods are currently under investigation and are expected to be included as a standard of care in the coming years. However, clinicians have to be aware that any progress in medicine is not possible without the development of basic sciences.

The aim of this Special Issue of Cancers is to provide a platform for researchers and practitioners to present their high-quality original and review papers covering the results of basic research, as well as clinical investigations dedicated to extending our knowledge of ovarian, endometrial, cervical and vulvar cancer.

The scope of this Special Issue includes reports of both surgical and medical interventions aiming to improve the diagnostics and treatment of gynecologic cancer. Articles based on experimental results will provide novel insights into the biology of gynecologic malignancies, and reports of well-designed experiments employing novel drugs will be welcome.

This Special issue will highlight new, multidisciplinary approaches to research in the field, and will indicate further directions for future development. 

Dr. Marcin Bobiński
Dr. Monika Abramiuk
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ovarian cancer
  • endometrial cancer
  • cervical cancer
  • targeted therapy
  • tumor immunity
  • tumor microenvironment
  • gynecological surgery
  • gynecologic oncology

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

20 pages, 1816 KiB  
Review
Navigating Fertility Preservation Options in Gynecological Cancers: A Comprehensive Review
by Elena Chitoran, Vlad Rotaru, Madalina-Nicoleta Mitroiu, Cristiana-Elena Durdu, Roxana-Elena Bohiltea, Sinziana-Octavia Ionescu, Aisa Gelal, Ciprian Cirimbei, Mihnea Alecu and Laurentiu Simion
Cancers 2024, 16(12), 2214; https://doi.org/10.3390/cancers16122214 - 13 Jun 2024
Viewed by 401
Abstract
(1) Background: Currently, an increasing number of women postpone pregnancy beyond the age of 35. Gynecological cancers affect a significant proportion of women of reproductive age, necessitating the development of fertility preservation methods to fulfill family planning. Consequently, providing treatment options that preserve [...] Read more.
(1) Background: Currently, an increasing number of women postpone pregnancy beyond the age of 35. Gynecological cancers affect a significant proportion of women of reproductive age, necessitating the development of fertility preservation methods to fulfill family planning. Consequently, providing treatment options that preserve fertility in women diagnosed with gynecological cancers has become a crucial component of care for survivors. (2) Methods: We conducted an extensive search of relevant scientific publications in PubMed and Embase databases and performed a narrative review, including high-quality peer-reviewed research on fertility after being treated for gynecologic cancers, reporting pregnancy rates, birth rates, and pregnancy outcomes in cancer survivors as well as therapeutic options which partially preserve fertility and methods for obtaining a pregnancy in survivors. (3) Discussion: The medicine practiced today is focused on both treating the neoplasm and preserving the quality of life of the patients, with fertility preservation being an important element of this quality. This leads to an improved quality of life, allowing these women to become mothers even in the seemingly adverse circumstances posed by such a pathology. However, although there are guidelines on female fertility preservation in the context of neoplasms, an analysis shows that physicians do not routinely consider it and do not discuss these options with their patients. (4) Conclusions: Advancements in medicine have led to a better understanding and management of gynecological neoplasms, resulting in increased survival rates. Once the battle against these neoplasms is won, the issue of preserving the quality of life for these women arises, with fertility preservation being an important aspect for women who have not yet fulfilled their family planning desires at the time of diagnosis. It is important for patients to be informed about the available options for fertility preservation and to be encouraged to make informed decisions in collaboration with their medical team. Standardized recommendations for onco-fertility into guidelines should be taken into consideration in the future. Full article
(This article belongs to the Special Issue Novel Approaches to Gynecologic Cancers Biology and Treatment)
Show Figures

Figure 1

Back to TopTop