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Cancers
Special Issues
The Tumor Microenvironment Polarization as a Goal of Cancer Immunotherapy
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The Tumor Microenvironment Polarization as a Goal of Cancer Immunotherapy

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 7242

Special Issue Editors

Dr. Ryszard Smolarczyk

E-Mail Website
Guest Editor
Center for Translational Research and Molecular Biology of Cancer, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, Wybrzeże Armii Krajowej Street 15, 44-102 Gliwice, Poland
Interests: anti-cancer therapy; tumor blood vessels; vascular disrupting agents (VDAs); tumor microenvironment; combined therapy; radiotherapy; tumor targeting drugs; polymer drug nanocarriers; hypoxia; cell therapy
Dr. Justyna Czapla

E-Mail Website
Guest Editor
Center for Translational Research and Molecular Biology of Cancer, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, Wybrzeże Armii Krajowej Street 15, 44-102 Gliwice, Poland
Interests: the tumor microenvironment; cancer associated fibroblasts; natural killers; macrophages; immunotherapy; anti-cancer therapy; cell therapy; vascular disrupting agents (VDAs)

Special Issue Information

Dear Colleagues, 

Successful immunotherapy depends on efficient activation of host immune cells to fight against cancer but also on sustained immunostimulatory milieu. The tumor microenvironment (TME) which consists of non-malignant cells such as stromal cells (cancer associated fibroblasts (CAF)), immune and inflammatory cells (neutrophils, macrophages, NK cells, lymphocytes), cells of the vascular system, creates supportive and immunosuppressive milieu for tumor growth. Reversal of tumor promoting properties of the TME towards tumoricidal and immunostimulatory is promising strategy to improve response to immunotherapy. Turning “cold” tumor milieu into “hot” one enhances immunogenicity, restores immune cytotoxic activity and favors anti-tumor immunity.

This Special Issue aims to highlight recent advances on microenvironment-polarizing combinations for cancer immunotherapy.

We are pleased to invite you to submit an original research or state of art review on all aspects of the TME alterations to improve immunotherapy outcomes. Research areas may include (but are not limited to) the following: application of various strategy (e.g. cell therapy, new drugs, new combination treatments) aimed at the TME polarization. Detailed issues may concern influence of cellular and acellular components of the TME on tumors immunosuppression and response to immunotherapy, immunotherapy strategies highlighting problems, solutions and future directions in anti-cancer therapy.

Dr. Ryszard Smolarczyk
Dr. Justyna Czapla
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunotherapy
  • tumor microenvironment polarization
  • immune cells
  • macrophages
  • NK cells
  • tumor-infiltrating lymphocytes
  • neutrophils
  • cancer associated fibroblasts
  • tumor blood vessels
  • anti-cancer therapy

Published Papers (2 papers)

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Review

25 pages, 1621 KiB  
Review
Circulating and Tumor-Associated Neutrophils in the Era of Immune Checkpoint Inhibitors: Dynamics, Phenotypes, Metabolism, and Functions
by Lara Gibellini, Rebecca Borella, Elena Santacroce, Eugenia Serattini, Federica Boraldi, Daniela Quaglino, Beatrice Aramini, Sara De Biasi and Andrea Cossarizza
Cancers 2023, 15(13), 3327; https://doi.org/10.3390/cancers15133327 - 24 Jun 2023
Cited by 5 | Viewed by 1771
Abstract
Neutrophils are the most abundant myeloid cells in the blood and are a considerable immunological component of the tumor microenvironment. However, their functional importance has often been ignored, as they have always been considered a mono-dimensional population of terminally differentiated, short-living cells. During [...] Read more.
Neutrophils are the most abundant myeloid cells in the blood and are a considerable immunological component of the tumor microenvironment. However, their functional importance has often been ignored, as they have always been considered a mono-dimensional population of terminally differentiated, short-living cells. During the last decade, the use of cutting-edge, single-cell technologies has revolutionized the classical view of these cells, unmasking their phenotypic and functional heterogeneity. In this review, we summarize the emerging concepts in the field of neutrophils in cancer, by reviewing the recent literature on the heterogeneity of both circulating neutrophils and tumor-associated neutrophils, as well as their possible significance in tumor prognosis and resistance to immune checkpoint inhibitors. Full article
(This article belongs to the Special Issue The Tumor Microenvironment Polarization as a Goal of Cancer Immunotherapy)
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29 pages, 2469 KiB  
Review
Anti-Tumor Strategies by Harnessing the Phagocytosis of Macrophages
by Si-Yuan Li, Yong-Lin Guo, Jia-Wen Tian, He-Jing Zhang, Rui-Fang Li, Ping Gong and Zi-Li Yu
Cancers 2023, 15(10), 2717; https://doi.org/10.3390/cancers15102717 - 11 May 2023
Cited by 9 | Viewed by 5170
Abstract
Macrophages are essential for the human body in both physiological and pathological conditions, engulfing undesirable substances and participating in several processes, such as organism growth, immune regulation, and maintenance of homeostasis. Macrophages play an important role in anti-bacterial and anti-tumoral responses. Aberrance in [...] Read more.
Macrophages are essential for the human body in both physiological and pathological conditions, engulfing undesirable substances and participating in several processes, such as organism growth, immune regulation, and maintenance of homeostasis. Macrophages play an important role in anti-bacterial and anti-tumoral responses. Aberrance in the phagocytosis of macrophages may lead to the development of several diseases, including tumors. Tumor cells can evade the phagocytosis of macrophages, and “educate” macrophages to become pro-tumoral, resulting in the reduced phagocytosis of macrophages. Hence, harnessing the phagocytosis of macrophages is an important approach to bolster the efficacy of anti-tumor treatment. In this review, we elucidated the underlying phagocytosis mechanisms, such as the equilibrium among phagocytic signals, receptors and their respective signaling pathways, macrophage activation, as well as mitochondrial fission. We also reviewed the recent progress in the area of application strategies on the basis of the phagocytosis mechanism, including strategies targeting the phagocytic signals, antibody-dependent cellular phagocytosis (ADCP), and macrophage activators. We also covered recent studies of Chimeric Antigen Receptor Macrophage (CAR-M)-based anti-tumor therapy. Furthermore, we summarized the shortcomings and future applications of each strategy and look into their prospects with the hope of providing future research directions for developing the application of macrophage phagocytosis-promoting therapy. Full article
(This article belongs to the Special Issue The Tumor Microenvironment Polarization as a Goal of Cancer Immunotherapy)
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