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The Biomarkers and Detection of Head and Neck Cancer (Volume...
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The Biomarkers and Detection of Head and Neck Cancer (Volume II)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Biomarkers".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 2664

Special Issue Editors

Dr. Sophie Martin

E-Mail Website
Guest Editor
Laboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Strasbourg, France
Interests: head and neck cancer; therapy resistance; immunotherapy; tumoroid; biomarkers
Special Issues, Collections and Topics in MDPI journals
Dr. Alain C. Jung

E-Mail Website
Guest Editor
STREINTH, Inserm IRFAC U1113, Strasbourg France and Laboratory of Tumor Biology, Institut de Cancérologie Strasbourg Europe, 67065 Strasbourg, France
Interests: HPV-related head and neck cancer; immunogenic cell death; immunotherapy; microenvironment
Special Issues, Collections and Topics in MDPI journals
Dr. Mickaël Burgy

E-Mail Website
Guest Editor
Department of Medical Oncology, Institut de Cancérologie Strasbourg Europe and Laboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Strasbourg, France
Interests: head and neck cancer; patient care; innovative therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the second edition of "Biomarkers and Detection of Head and Neck Cancer" (https://www.mdpi.com/journal/cancers/special_issues/Biomarkers_Detection_Head_and_Neck_Cancer).

Head and neck squamous cell carcinomas (HNSCCs) represent the fifth most common cancer worldwide, with an annual incidence and mortality estimated to be approximately 600,000 and 375,000 cases, respectively. HNSCCs are related to alcohol and tobacco consumption and infection by high-risk Human Papillomaviruses (HPVs). Most patients present with advanced disease due to late diagnosis, and survival outcomes therefore remain poor, despite advances in therapeutic management and decades of research. In addition, conventional therapies including surgery and chemoradiation can leave survivors with significant morbidity and reduced quality of life. Immunotherapies have improved survival, but a durable response is observed in less than 20% of patients. Unlike other cancers, HNSCCs suffer from the absence of reliable diagnostic, prognostic, predictive, and theragnostic biomarkers. These markers are urgently needed in order to offer patients tailored therapeutic options that target specific molecular features of HNSCCs subgroups, to predict cancer cell resistance to treatment and detect the occurrence of relapse early.

In this Special Issue, we are inviting original research articles, reviews, and perspectives to present and discuss data on the biomarkers and detection of these tumors. Topics will include but are not limited to the biology and genomic characteristics of these cancers; the coding and noncoding transcriptome; the role of extracellular vesicles; biomarkers in tissue, blood, and biofluids; “liquid biopsies”; original tumor models such as tumoroids and tumoroids-on-chips; the identification of novel therapeutic targets or resistance mechanisms; and new approaches for treating these cancers. Work including multidisciplinary approaches (chemistry, physics, engineering, etc.) are welcome.

Dr. Sophie Martin
Dr. Alain C. Jung
Dr. Mickaël Burgy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers
  • liquid biopsies
  • tumoroids
  • targets
  • therapy

Published Papers (2 papers)

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Research

16 pages, 749 KiB  
Article
DNA Double-Strand Break Response and Repair Gene Polymorphisms May Influence Therapy Results and Prognosis in Head and Neck Cancer Patients
by Dorota Butkiewicz, Małgorzata Krześniak, Agnieszka Gdowicz-Kłosok, Krzysztof Składowski and Tomasz Rutkowski
Cancers 2023, 15(20), 4972; https://doi.org/10.3390/cancers15204972 - 13 Oct 2023
Cited by 1 | Viewed by 1214
Abstract
Radiotherapy and cisplatin-based chemotherapy belong to the main treatment modalities for head and neck squamous cell carcinoma (HNSCC) and induce cancer cell death by generating DNA damage, including the most severe double-strand breaks (DSBs). Alterations in DSB response and repair genes may affect [...] Read more.
Radiotherapy and cisplatin-based chemotherapy belong to the main treatment modalities for head and neck squamous cell carcinoma (HNSCC) and induce cancer cell death by generating DNA damage, including the most severe double-strand breaks (DSBs). Alterations in DSB response and repair genes may affect individual DNA repair capacity and treatment sensitivity, contributing to the therapy resistance and poor prognosis often observed in HNSCC. In this study, we investigated the association of a panel of single-nucleotide polymorphisms (SNPs) in 20 DSB signaling and repair genes with therapy results and prognosis in 505 HNSCC patients treated non-surgically with DNA damage-inducing therapies. In the multivariate analysis, there were a total of 14 variants associated with overall, locoregional recurrence-free or metastasis-free survival. Moreover, we identified 10 of these SNPs as independent predictors of therapy failure and unfavorable prognosis in the whole group or in two treatment subgroups. These were MRE11 rs2155209, XRCC5 rs828907, RAD51 rs1801321, rs12593359, LIG4 rs1805388, CHEK1 rs558351, TP53 rs1042522, ATM rs1801516, XRCC6 rs2267437 and NBN rs2735383. Only CHEK1 rs558351 remained statistically significant after correcting for multiple testing. These results suggest that specific germline variants related to DSB response and repair may be potential genetic modifiers of therapy effects and disease progression in HNSCC treated with radiotherapy and cisplatin-based chemoradiation. Full article
(This article belongs to the Special Issue The Biomarkers and Detection of Head and Neck Cancer (Volume II))
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21 pages, 7121 KiB  
Article
USP14 Positively Modulates Head and Neck Squamous Carcinoma Tumorigenesis and Potentiates Heat Shock Pathway through HSF1 Stabilization
by Jie Wang, Yuandi Xiang, Zhanghong Xie, Mengqi Fan, Shizhen Fang, Huanzhi Wan, Rui Zhao, Feng Zeng and Qingquan Hua
Cancers 2023, 15(17), 4385; https://doi.org/10.3390/cancers15174385 - 1 Sep 2023
Cited by 2 | Viewed by 1161
Abstract
The ubiquitin-proteasome system is a pivotal intracellular proteolysis process in posttranslational modification. It regulates multiple cellular processes. Deubiquitinating enzymes (DUBs) are a stabilizer in proteins associated with tumor growth and metastasis. However, the link between DUBs and HNSCC remains incompletely understood. In this [...] Read more.
The ubiquitin-proteasome system is a pivotal intracellular proteolysis process in posttranslational modification. It regulates multiple cellular processes. Deubiquitinating enzymes (DUBs) are a stabilizer in proteins associated with tumor growth and metastasis. However, the link between DUBs and HNSCC remains incompletely understood. In this study, therefore, we identified USP14 as a tumor proliferation enhancer and a substantially hyperactive deubiquitinase in HNSCC samples, implying a poor prognosis prediction. Silencing USP14 in vitro conspicuously inhibited HNSCC cell proliferation and migration. Consistently, defective USP14 in vivo significantly diminished HNSCC tumor growth and lung metastasis compared to the control group. Luciferase assays indicated that HSF1 was downstream from USP14, and an evaluation of the cellular effects of HSF1 overexpression in USP14-dificient mice tumors showed that elevated HSF1 reversed HNSCC growth and metastasis predominantly through the HSF1-HSP pathway. Mechanistically, USP14 encouraged HSF1 expression by deubiquitinating and stabilizing HSF1, which subsequently orchestrated transcriptional activation in HSP60, HSP70, and HSP90, ultimately leading to HNSCC progression and metastasis. Collectively, we uncovered that hyperactive USP14 contributed to HNSCC tumor growth and lung metastasis by reinforcing HSF1-depedent HSP activation, and our findings provided the insight that targeting USP14 could be a promising prognostic and therapeutic strategy for HSNCC. Full article
(This article belongs to the Special Issue The Biomarkers and Detection of Head and Neck Cancer (Volume II))
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